Glucagon Secretion, Function, and Clinical Role

  • Richard E. Dobbs
  • Roger H. Unger


The cellular arrangement of the islets of Langerhans consists of an outer mantle of glucagon-containing A cells or, in some islets, pancreatic-polypeptide-containing F cells making up approximately 25% of the total islet cell population, somatostatin-containing D cells making up about 10%, and an inner core of insulincontaining B cells accounting for at least 65% of the total islet cell population (Orci and Unger, 1976).


Vasoactive Intestinal Polypeptide Glucagon Secretion Hepatic Glucose Production Gastric Inhibitory Polypeptide Glucagon Level 
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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Richard E. Dobbs
    • 1
  • Roger H. Unger
    • 2
    • 3
  1. 1.Department of PhysiologyUniversity of Texas Health Science Center at DallasDallasUSA
  2. 2.Department of Internal MedicineUniversity of Texas Health Science Center at DallasDallasUSA
  3. 3.Veterans Administration Medical CenterDallasUSA

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