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The Divalent Ions Calcium, Phosphorus, and Magnesium and Vitamin D

  • Nachman Brautbar
  • David B. N. Lee
  • Charles R. Kleeman

Abstract

There is an increasing general appreciation of the critical role of calcium as a regulator in all kinds of cells and in organisms of all levels of complexity. It may be the single most universal transducer or messenger in biological life, coupling extracellular stimuli with subsequent intracellular events. Even the simplest organisms appear to employ calcium; it regulates chemotactic behavior (Ordal, 1977) and sporulation (Golub and Bronner, 1974) and it has been adapted to more and more uses in multicellular organisms. Cell aggregation, cell-cell com munication, membrane integrity and permeability, microtubular assembly, cell division and growth, blood coagulation, hormone-response coupling, and electrical stimulus-response coupling, including all muscle contraction and neurotransmitter release, all require calcium and are to some degree regulated by it (Parfitt and Kleerekoper, 1980b).

Keywords

Parathyroid Hormone Primary Hyperparathyroidism Magnesium Deficiency Renal Osteodystrophy Intestinal Calcium Absorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Nachman Brautbar
    • 1
  • David B. N. Lee
    • 2
  • Charles R. Kleeman
    • 3
  1. 1.Department of Medicine, Division of NephrologyUniversity of Southern California Medical SchoolLos AngelesUSA
  2. 2.Department of Medicine, Division of NephrologyUniversity of California at Los Angeles-San Fernando Valley ProgramLos AngelesUSA
  3. 3.Department of Medicine, Division of NephrologyUniversity of California at Los Angeles Health Science Center and Wadsworth Veterans Administration Medical CenterLos AngelesUSA

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