Metabolic Aspects of Urinary Stone Disease

  • Edwin L. PrienJr.
  • Hibbard E. Williams


The field of urinary stone disease can conveniently be divided into those diseases that clearly result from excessive supersaturation of the urine for the offending crystalline species and those that do not. Recent developments in the former area are mainly confined to describing new disorders or improving therapy; there is little debate on pathogenesis and hardly a reference to physical chemistry. For calcium stone disease, the situation is quite different. Not only is excessive supersaturation for calcium oxalate often difficult to demonstrate, but normals may have crystalluria. The lofty realms of complex physical chemistry are increasingly invoked. Further, in contrast to other stone diseases, the contribution of diet to both the cause and treatment of calcium stone disease must be considered. It is this disease entity that presents the greatest continuing challenge.


Primary Hyperparathyroidism Calcium Oxalate Stone Disease Urinary Oxalate Intestinal Calcium Absorption 
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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Edwin L. PrienJr.
    • 1
    • 2
  • Hibbard E. Williams
    • 3
  1. 1.Harvard Medical SchoolBostonUSA
  2. 2.Massachusetts General HospitalBostonUSA
  3. 3.Department of MedicineUniversity of California at Davis, School of MedicineDavisUSA

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