Molecular Basis of Self/Non-self Discrimination in the Invertebrata

  • Peter L. Ey
  • Charles R. Jenkin


In 1907 Reudiger and Davis claimed that hemolymph from several different species of invertebrates promoted the ingestion of bacteria by human polymorphonuclear leukocytes and suggested on this basis that invertebrates may possess factors (opsonins) which play an important role in enchancing phagocytosis. This particular field lay relatively dormant for almost 60 years until Tripp (1966) showed in vitro that hemolymph from the oyster Crassostrea virginica increased the rate of phagocytosis of erythrocytes by amebocytes from this animal. Two years later Stuart (1968) found that the blood cells of the octopus Eledone cirrosa would phagocytose erythrocytes only if they had been pretreated with hemolymph. Unfortunately, in neither investigation was the specificity of these factors investigated.


Human Erythrocyte Horseshoe Crab Sheep Erythrocyte Hemagglutinating Activity Helix Pomatia 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter L. Ey
    • 1
  • Charles R. Jenkin
    • 1
  1. 1.Department of Microbiology and ImmunologyThe University of AdelaideAdelaideAustralia

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