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Aging and Functions of the RES

  • Richard H. Weindruch
  • Roy L. Walford

Abstract

Among the most striking alterations occurring with aging are those involving the immune apparatus. These alterations are of two different categories and affect thymus-dependent functions to a greater extent than thymus-independent functions. A decreased proliferative and/or functional response capacity to a wide array of exogenous stimuli occurs postpubertally together with an age-dependent increase in autoimmune phenomena. The first category has been amply documented via standard tests including lymphocyte proliferation following mitogen stimulation, mixed lymphocyte reaction (MLR), humoral immune responses, and T-cell-mediated cytolysis. The second category, though clinically appreciated in its later and grosser expressions, has not been as well studied immunologically due perhaps to a lack of assay systems to measure the apparently subtle losses in self tolerance brought on by normal aging.

Keywords

Spleen Cell Young Mouse Splenic Cell Thymic Involution Immunological Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Richard H. Weindruch
    • 1
  • Roy L. Walford
    • 1
  1. 1.Department of Pathology, School of MedicineUniversity of CaliforniaLos AngelesUSA

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