Ontogeny of Cellular Immune Reactivity in the Mouse

  • Robert Auerbach
  • Amiela Globerson
  • Tehila Umiel


Developmental immunology, once a peripheral area of investigation, has become a central arena for studies directed at understanding the nature of molecular diversification, for analysis of the expansion of specific antibody-forming clones, for investigations into the sequential changes accompanying immunoglobulin production following antigenic challenge, and indeed for research aimed at resolving the basic steps of gene replication, transcription, and translation as these are influenced during the maturation of the cells that comprise the B-cell system responsible for antibody production. The literature dealing with the ontogeny of B cells is overwhelming as is the information that is becoming available concerning the postnatal and poststimulatory changes that occur in B cells even after functional maturation has been largely completed.


Fetal Liver Suppressor Cell Effector Organ Splenic Cell Fetal Liver Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert Auerbach
    • 1
  • Amiela Globerson
    • 2
  • Tehila Umiel
    • 2
  1. 1.Department of ZoologyUniversity of WisconsinMadisonUSA
  2. 2.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

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