Ontogeny of Immunological Functions in Amphibians

  • Louis Du Pasquier


The theoretical basis for studying the ontogeny of immunological function in amphibians is linked to aspects of amphibian embryonic and larval development. The free-swimming larval period, the absence of maternal-fetal interactions, the relative simplicity of the larval immune system, and metamorphosis with its associated differentiation of adult antigens, all pose a variety of interesting problems to the developing immune system and to developmental immunologists. Answers to these problems can provide information in at least three major areas of research in immunology: the origin of antibody diversity, the role of the thymus, and the generation of tolerance to self. Moreover, the comparison between the development of the strikingly different immune systems of urodeles and anurans can reveal the phylogenetic aspects of some components of the immune system. During the past decade, amphibian models have been significantly refined largely due to the introduction: of biologically defined strains both in urodeles and in anurans (De Lanney and Blackler, 1969; Charlemagne and Tournefier, 1974; Nace and Richards, 1969; Kobel and Du Pasquier, 1977; Tochinai and Katagiri, 1975); of clones of isogenic and histocompatibility-defined Xenopus (Kobel and Du Pasquier, 1975, 1977); of natural (Tymowska and Fischberg, 1973) and laboratory-made polyploid species of Xenopus (Du Pasquier et al., 1977); and finally, of hyperdiploid Xenopus hybrids convenient for gene mapping (Kobel and Du Pasquier, 1979; Du Pasquier and Kobel, 1979).


Xenopus Laevis Allograft Rejection Graft Rejection Histocompatibility Antigen Skin Allograft 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Louis Du Pasquier
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

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