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Biology of Marek’s Disease Virus and the Herpesvirus of Turkeys

  • Laurence Noel Payne
Part of the The Viruses book series (VIRS)

Abstract

Marek’s disease (MD) is a lymphoproliferative disorder of the domestic chicken caused by a herpesvirus and is characterized principally by T- cell lymphoma formation and a demyelinative peripheral neuropathy. It is named after Marek (1907), who first described the neural form of the disease; an associated visceral lymphomatosis was reported later by Pappenheimer et al. (1926, 1929a,b).

Keywords

Vaccinal Immunity Duck Embryo Fibroblast Transient Paralysis IARC Scientific Publication Avian Pathol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adldinger, H.K., and Calnek, B.W., 1973, Pathogenesis of Marek’s disease: Early distribution of virus and viral antigens in infected chickens, J. Natl. Cancer Inst. 50:1287.Google Scholar
  2. Akiyama, Y., and Kato, S., 1974, Two Cell lines from lymphomas of Marek’s disease, Biken J. 17:105.PubMedGoogle Scholar
  3. Akiyama, Y., Kato, S., and Iwa, N., 1973, Continuous cell culture from lymphoma of Marek’s disease, Biken J. 16:177.PubMedGoogle Scholar
  4. Anderson, D.P., King, D.D., Eidson, C.S., and Kleven, S.H., 1972, Filtered air positive pressure (FAPP) brooding of broiler chickens, Avian Dis. 16:20.PubMedCrossRefGoogle Scholar
  5. Anonymous, 1941, Tentative pathologic nomenclature for the disease and/or disease complex variously designated as fowl leucemia, leucosis, range paralysis, fowl paralysis, iritis, lymphomatosis, lymphocytoma, neurolymphomatosis, leucotic tumors, leuce-moid diseases, etc., Am. J. Vet. Res. 2.116.Google Scholar
  6. Asmundson, V.S., and Biely, J., 1932, Inheritance of resistance to fowl paralysis (neurolymphomatosis gallinarum). 1. Differences in susceptibility, Can. J. Res. 6:171.CrossRefGoogle Scholar
  7. Ball, R.F., and Lyman, J.F., 1977, Revaccination of chicks for Marek’s disease at twenty-one days old, Avian Dis. 21:440.PubMedCrossRefGoogle Scholar
  8. Ball, R.F., Hill, J.F., Lyman, J., and Wyatt, A., 1971, The resistance to Marek’s disease of Chicks from immunized breeders, Poult. Sci. 50:1084.PubMedGoogle Scholar
  9. Bankowski, R.A., Moulton, J.E., and Mikami, T., 1969, Characterization of Cal-1 strain of acute Marek’s disease agent, Am. J. Vet. Res. 30:1667.PubMedGoogle Scholar
  10. Baxendale, W., 1969, Preliminary observations on Marek’s disease in ducks and other avian species, Vet. Rec. 85:341.PubMedCrossRefGoogle Scholar
  11. Beasley, J.N., Patterson, L.T., and McWade, D.H., 1970, Transmission of Marek’s disease by poultry house dust and Chicken dander, Am. J. Vet. Res. 31:339.PubMedGoogle Scholar
  12. Benton, W.J., and Cover, M.S., 1957, The increased incidence of visceral lymphomatosis in broiler and replacement birds, Avian Dis. 1:320.CrossRefGoogle Scholar
  13. Biggs, P.M., 1961, A discussion on the Classification of the avian leucosis Complex and fowl paralysis, Br. Vet. J. 117:326.Google Scholar
  14. Biggs, P.M., 1968, Marek’s disease—current state of knowledge, Cun. Top. Microbiol. Immunol. 43:91.Google Scholar
  15. Biggs, P.M., 1975, Vaccination against oncogenic herpesviruses—a review, in: Oncogenesis and Herpesviruses II (G. de Thé, M.A. Epstein, and H. zur Hausen, eds.), pp. 317–322, IARC Scientific Publication No. 11, International Agency for Research on Cancer, Lyon.Google Scholar
  16. Biggs, P.M. (ed.), 1980, Resistance and Immunity to Marek’s Disease, CEC Publication EUR 6470, Luxembourg, 617 pp.Google Scholar
  17. Biggs, P.M., and Milne, B.S., 1971, Use of the embryonating egg in studies on Marek’s disease, Am. J. Vet. Res. 32:1795.PubMedGoogle Scholar
  18. Biggs, P.M., and Milne, B.S., 1972, Biological properties of a number of Marek’s disease virus isolates, in: Oncogenesis and Herpesviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 88–94, IARC Scientific Publication No. 2, International Agency for Research on Cancer, Lyon.Google Scholar
  19. Biggs, P.M., and Payne, L.N., 1963, Transmission experiments with Marek’s disease (fowl paralysis), Vet. Rec. 75:177.Google Scholar
  20. Biggs, P.M., and Payne, L.N., 1964, Relationship of Marek’s disease (neural lymphomatosis) to lymphoid leukosis, Natl. Cancer Inst. Monogr. 17:83.Google Scholar
  21. Biggs, P.M., and Payne, L.N., 1967, Studies on Marek’s disease. I. Experimental transmission, J. Natl. Cancer Inst. 39:267.PubMedGoogle Scholar
  22. Biggs, P.M., Purchase, H.G., Bee, B.R., and Dalton, P.J., 1965, Preliminary report on acute Marek’s disease (fowl paralysis) in Great Britain, Vet. Rec. 77:1339.PubMedCrossRefGoogle Scholar
  23. Biggs, P.M., Long, P.L., Kenzy, S.G., and Rootes, D.G., 1968a, Relationship between Marek’s disease and Coccidiosis. II. The effect of Marek’s disease on the susceptibility of Chickens to Coccidial infection, Vet. Rec. 83:284.PubMedCrossRefGoogle Scholar
  24. Biggs, P.M., Thorpe, R.J., and Payne, L.N., 1968b, Studies on genetic resistance to Marek’s disease in the domestic Chicken, Br. Poult. Sci. 9:37.PubMedCrossRefGoogle Scholar
  25. Biggs, P.M., Payne, L.N., Milne, B.S., Churchill, A.E., Chubb, R.C., Powell, D.G., and Harris, A.H., 1970, Field trials with an attenuated Cell associated vaccine for Marek’s disease, Vet. Rec. 87:704.PubMedCrossRefGoogle Scholar
  26. Biggs, P.M., Powell, D.G., Churchill, A.E., and Chubb, R.G., 1972, The epizootiology of Marek’s disease. 1. Incidence of antibody, viraemia and Marek’s disease in six flocks, Avian Pathol. 1:5.PubMedCrossRefGoogle Scholar
  27. Biggs, P.M., Jackson, CA.W., and Powell, D.G., 1973, The epizootiology of Marek’s disease. 2. The effect of supply flock, rearing house and production house on the incidence of Marek’s disease, Avian Pathol. 2:127.PubMedGoogle Scholar
  28. Blaxland, J.D., MacLeod, A.J., Baxendale, W., and Hall, T., 1972, Observations on field trials with an experimental attenuated Marek’s disease virus vaccine, Vet. Rec. 90:431.PubMedCrossRefGoogle Scholar
  29. Brewer, R.N., Reid, W.M., Johnson, J., and Schmittle, S.C., 1969, Studies on acute Marek’s disease. VIII. The role of mosquitoes in transmission under experimental Conditions, Avian Dis. 13:83.PubMedCrossRefGoogle Scholar
  30. Briles, W.E., and Stone, H.A., 1975, Relative influence of B isoalleles from lines N and P on Marek’s mortality, Poult. Sci. 54:1738.Google Scholar
  31. Briles, W.E., McGibbon, W.H., and Stone, H.A., 1976, Effects of B alloalleles from Regional Cornell Random bred stock on mortality from Marek’s disease, Poult. Sci. 55:2011.Google Scholar
  32. Briles, W.E., Stone, H.A., and Cole, R.K., 1977, Marek’s disease: Effects of B histocompatibility alloalleles in resistant and susceptible Chicken lines, Science 195:193.PubMedCrossRefGoogle Scholar
  33. Briles, W.E., Briles, R.W., McGibbon, W.H., and Stone, H.A., 1980, Identification of B alloalleles associated with resistance to Marek’s disease, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 395–416, CEC Publication EUR 6470, Luxembourg.Google Scholar
  34. Bülow, V. v., 1969, Marek’sche Huhnerlahmung: Reaktionen im experimentell infizierten embryonierten Ei, Zentralbl. Veterinaermed. 16:97.CrossRefGoogle Scholar
  35. Bülow, V. v., 1971, Diagnosis and Certain biological properties of the virus of Marek’s disease, Am. J. Vet. Res. 32:1275.Google Scholar
  36. Bülow, V. v., 1977, Further Characterization of the CVI 988 strain of Merek’s disease virus, Avian Pathol. 6:395.PubMedCrossRefGoogle Scholar
  37. Bülow, V. v., and Biggs, P.M., 1975a, Differentiation between strains of Marek’s disease vims and turkey herpesvirus by immunofluorescence assays, Avian Pathol. 4:133.PubMedGoogle Scholar
  38. Bülow, V. v., and Biggs, P.M., 1975b, Precipitating antigens associated with Marek’s disease viruses and a herpesvirus of turkeys, Avian Pathol. 4:147.PubMedGoogle Scholar
  39. Bülow, V. v., and Schmid, D.O., 1979, Antigenic Characteristics of Marek’s disease tumour cells, Avian Pathol. 8:265.PubMedCrossRefGoogle Scholar
  40. Burg, R. W., Feldbush, T., Morris, C.A., and Maag, T.A., 1971, Depression of thymus-and bursa-dependent immune systems of Chicks with Marek’s disease, Avian Dis. 15:662.PubMedCrossRefGoogle Scholar
  41. Burgoyne, G.H., and Witter, R.L., 1973, Effect of passively transferred immunoglobulins on Marek’s disease, Avian Dis. 17:824.PubMedCrossRefGoogle Scholar
  42. Burmester, B.R., and Witter, R.L., 1972, Efficiency of Commercial air filters against Marek’s disease virus, Appl. Microbiol. 23:505.PubMedGoogle Scholar
  43. Byerly, J.L., and Dawe, D.L., 1972, Delayed hypersensitivity reactions in Marek’s disease virus infected Chickens, Am. J. Vet. Res. 33:2267.PubMedGoogle Scholar
  44. Calnek, B.W., 1972a, Antibody development in Chickens exposed to Marek’s disease virus, in: Oncogenesis and Herpesviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 129–136, IARC Scientific Publication No. 2, International Agency for Research on Cancer, Lyon.Google Scholar
  45. Calnek, B.W., 1972b, Effects of passive antibody on early pathogenesis of Marek’s disease, Infect. Immun. 6:193.PubMedGoogle Scholar
  46. Calnek, B.W., 1973, Influence of age at exposure on the pathogenesis of Marek’s disease, J. Natl. Cancer Inst. 51:929.PubMedGoogle Scholar
  47. Calnek, B.W., 1980, Marek’s disease virus and lymphoma, in: Oncogenic Herpesviruses (F. Rapp, ed.), Vol. 1, pp. 103–143, CRC Press, Boca Raton, Florida.Google Scholar
  48. Calnek, B.W., and Adldinger, H.K., 1971, Some Characteristics of Cell-free preparations of Marek’s disease virus, Avian Dis. 15:508.PubMedCrossRefGoogle Scholar
  49. Calnek, B.W., and Hitchner, S.B., 1973, Survival and disinfection of Marek’s disease virus and the effectiveness of filters in preventing airborne dissemination, Poult. Sci. 52:35.PubMedGoogle Scholar
  50. Calnek, B.W., and Madin, S.H., 1969, Characteristics of in vitro infection of Chicken kidney cell Cultures with a herpesvirus from Marek’s disease, Am. J. Vet. Res. 30:1389.PubMedGoogle Scholar
  51. Calnek, B.W., and Payne, L.N., 1976, Lack of Correlation between Marek’s disease tumor induction and expression of endogenous avian RNA tumor virus genome, Int. J. Cancer 17:235.CrossRefGoogle Scholar
  52. Calnek, B.W., and Smith, M.W., 1972, Vaccination against Marek’s disease with Cell-free turkey herpesvirus: Interference by maternal antibody, Avian Dis. 16:954.PubMedCrossRefGoogle Scholar
  53. Calnek, B.W., and Witter, R.L., 1978, Marek’s disease, in: Diseases of Poultry (M.S. Hofstad, B.W. Calnek, C.F. Helmboldt, W.M. Reid, and H.W. Yoder, eds.), pp. 385–418, Iowa State University Press, Ames.Google Scholar
  54. Calnek, B.W., Madin, S.H., and Kinazeff, A.J., 1969, Susceptibility of Cultured mammalian cells to infection with a herpesvirus from Marek’s disease and T-virus from reticuloendotheliosis of Chickens, Am. J. Vet. Res. 30:1403.PubMedGoogle Scholar
  55. Calnek, B.W., Adldinger, H.K., and Kahn, D.E., 1970a, Feather follicle epithelium: A source of enveloped and infectious Cell-free herpesvirus from Marek’s disease, Avian Dis. 14:219.PubMedCrossRefGoogle Scholar
  56. Calnek, B.W., Hitchner, S.B., and Adldinger, H.K., 1970b, Lyophilization of Cell-free Marek’s disease herpesvirus and a herpesvirus from turkeys, Appl. Microbiol. 20:723.PubMedGoogle Scholar
  57. Calnek, B.W., Ubertini, T., and Adldinger, H.K., 1970c, Viral antigen, virus particles, and infectivity of tissues from Chickens with Marek’s disease, J. Natl. Cancer Inst. 45:351.Google Scholar
  58. Calnek, B.W., Higgins, D.A., and Fabricant, J., 1975, Rous sarcoma regression in Chickens resistant or susceptible to Marek’s disease, Avian Dis. 19:473.PubMedCrossRefGoogle Scholar
  59. Calnek, B.W., Fabricant, J., Schat, K.A., and Murthy, K.K., 1977, Pathogenicity of low-virulence Marek’s disease viruses in normal versus immunologically Compromised chickens, Avian Dis. 21:346.PubMedCrossRefGoogle Scholar
  60. Calnek, B.W., Fabricant, J., Schat, K.A., and Murthy, K.K., 1978a, Rejection of a transplantable Marek’s disease lymphoma in normal versus immunologically deficient Chickens, J. Natl. Cancer Inst. 60:623.PubMedGoogle Scholar
  61. Calnek, B.W., Murthy, K.K., and Schat, K.A., 1978b, Establishment of Marek’s disease lymphoblastoid Cell lines from transplantable versus primary lymphomas, Int. J. Cancer 21:100.PubMedCrossRefGoogle Scholar
  62. Calnek, B.W., Carlisle, J.C., Fabricant, J., Murthy, K.K., and Schat, K.A., 1979, Comparative pathogenesis studies with oncogenic and nononcogenic Marek’s disease viruses and turkey herpesvirus, Am. J. Vet. Res. 40:541.PubMedGoogle Scholar
  63. Calnek, B.W., Shek, W.R., and Schat, K.A., 1981a, Latent infections with Marek’s disease virus and turkey herpesvirus, J. Natl. Cancer Inst. 66:585.PubMedGoogle Scholar
  64. Calnek, B.W., Shek, W.R. and Schat, K.A., 1981b, Spontaneous and induced herpesvirus genome expression in Marek’s disease tumor Cell lines, Infect. Immun. 34:483.PubMedGoogle Scholar
  65. Campbell, J.G., 1954, Avian leucosis: A plea for Clarification, Proceedings of the 10th World’s Poultry Congress, (J.E. Wilson, ed.), pp. 193–197, Dept. Agriculture for Scotland, Edinburgh.Google Scholar
  66. Campbell, J.G., 1956, Leucosis and fowl paralysis Compared and Contrasted, Vet. Rec. 68:527.Google Scholar
  67. Campbell, J.G., 1961, A proposed Classsification of the leucosis Complex and fowl paralysis, Br. Vet. J. 117:316.PubMedGoogle Scholar
  68. Campbell, W.F., and Frankel, J.W., 1979, Enhanced oncornavirus expression in Marek’s disease tumors from specific-pathogen-free Chickens, J. Natl. Cancer Inst. 62:323.PubMedGoogle Scholar
  69. Carrozza, J.H., Fredrickson, T.N., Prince, R.P., and Luginbuhl, R.E., 1973, Role of desquamated epithelial cells in transmission of Marek’s disease, Avian Dis. 17:767.PubMedCrossRefGoogle Scholar
  70. Chen, J.H., and Purchase, H.G., 1970, Surface antigen on Chicken kidney cells infected with the herpesvirus of Marek’s disease, Virology 40:410.PubMedCrossRefGoogle Scholar
  71. Cho, B.R., 1975, Horizontal transmission of turkey herpesvirus to Chickens. IV. Viral maturation in the feather follicle epithelium, Avian Dis. 19:136.PubMedCrossRefGoogle Scholar
  72. Cho, B.R., 1976a, A possible association between plaque type and pathogenicity of Marek’s disease herpesvirus, Avian Dis. 20:324.PubMedCrossRefGoogle Scholar
  73. Cho, B.R., 1976b, Horizontal transmission of turkey herpesvirus to Chickens. 5. Airborne transmission between Chickens, Poult. Sci. 55:1830.PubMedGoogle Scholar
  74. Cho, B.R., 1981, A simple in vitro differentiation between turkey herpesvirus and Marek’s disease virus, Avian Dis. 25:839.PubMedCrossRefGoogle Scholar
  75. Cho, B.R., and Kenzy, S.G., 1972, Isolation and Characterization of an isolate (HN) of Marek’s disease virus with low pathogenicity, Appl. Microbiol. 24:299.PubMedGoogle Scholar
  76. Cho, B.R., and Kenzy, S.G., 1975, Virologie and serologic studies of zoo birds for Marek’s disease virus infection, Infect. Immun. 11:809.PubMedGoogle Scholar
  77. Cho, B.R., Balch, R.K., and Hill, R.W., 1976, Marek’s disease vaccine breaks: Differences in viremia of vaccinated Chickens between those with and without Marek’s disease, Avian Dis. 20:496.PubMedCrossRefGoogle Scholar
  78. Chomiak, T.W., Luginbuhl, R.E., Helmboldt, C.F., and Kottaridis, S.D., 1967, Marek’s disease. 1. Propagation of the Connecticut A (Conn-A) isolate in Chicks, Avian Dis. 11:646.PubMedCrossRefGoogle Scholar
  79. Chubb, L.G., and Gordon, R.F., 1957, The avian leucosis Complex—a review, Vet. Rev. Annot. 3:97.Google Scholar
  80. Chubb, R.C., and Churchill, A.E., 1968, Precipitating antibodies associated with Marek’s disease, Vet. Rec. 83:4.Google Scholar
  81. Chubb, R.C., and Churchill, A.E., 1969, Effect of maternal antibody on Marek’s disease, Vet. Rec. 85:303.PubMedCrossRefGoogle Scholar
  82. Churchill, A.E., 1968, Herpes-type virus isolated in Cell Culture from tumors of Chickens with Marek’s disease. 1. Studies in Cell Culture, J. Natl. Cancer Inst. 41:939.PubMedGoogle Scholar
  83. Churchill, A.E., and Biggs, P.M., 1967, Agent of Marek’s disease in tissue Culture, Nature (London) 215:528.CrossRefGoogle Scholar
  84. Churchill, A.E., Chubb, R.C., and Baxendale, W., 1969a, The attenuation, with loss of oncogenicity, of the herpestype virus of Marek’s disease (strain HPRS-16) on passage in Cell Culture, J. Gen. Virol. 4:557.PubMedCrossRefGoogle Scholar
  85. Churchill, A.E., Payne, L.N., and Chubb, R.C., 1969b, Immunization against Marek’s disease using a live attenuated virus, Nature (London) 221:744.CrossRefGoogle Scholar
  86. Churchill, A.E., Baxendale, W., and Carrington, G., 1973, Viremia and antibody development in Chicks following the administration of turkey herpesvirus, Vet. Rec. 92:327.PubMedCrossRefGoogle Scholar
  87. Cole, R.K., 1968, Studies on genetic resistance to Marek’s disease, Avian Dis. 12:9.PubMedCrossRefGoogle Scholar
  88. Cole, R.K., 1972, The genetics of resistance to Marek’s disease, in: Oncogenesis and Herpesviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 123–128, IARC Scientific Publication No. 2, International Agency for Research on Cancer, Lyon.Google Scholar
  89. Cole, R.K., and Hutt, F.B., 1973, Selection and heterosis in Cornell White Leghorns: A review, with special Consideration of interstrain hybrids, Anim. Breeding Abstr. 41:103.Google Scholar
  90. Coleman, R.M., and Schierman, L.W., 1980, Independence of Chicken major histocompatibility antigens and tumor-associated antigen on the surface of herpes-induced lymphoma cells, Infect. Immun. 29:1067.PubMedGoogle Scholar
  91. Colmano, G., and Gross, W.B., 1971, Effect of metyrapone and DDD on infectious diseases, Poult. Sci. 51:850.Google Scholar
  92. Colwell, W.M., and Schmittle, S.C., 1968, Studies on acute Marek’s disease. VII. Airborne transmission of the GA isolate, Avian Dis. 12:724.PubMedCrossRefGoogle Scholar
  93. Colwell, W.M., Simmons, D.G., and Muse, K.E., 1974, Use of Japanese quail embryo fibroblast cells for propagation and assay of turkey herpesvirus FC-126, Appl. Microbiol. 27:218.PubMedGoogle Scholar
  94. Colwell, W.M., Simmons, D.G., Harris, J.R., Fulp, T.G., Carrozza, J.H., and Maag, T.A., 1975, Influence of some physical factors on Marek’s disease vaccine virus, Avian Dis. 19:781.PubMedCrossRefGoogle Scholar
  95. Confer, A.W., and Adldinger, H.K., 1980, Cell-mediated immunity in Marek’s disease: Cytotoxic responses in resistant and susceptible Chickens and relation to disease, Am. J. Vet. Res. 41:307.PubMedGoogle Scholar
  96. Confer, A.W., and Adldinger, H.K., 1981, The in vivo effect of levamisole on phytohae-magglutinin stimulation of lymphocytes in normal and Marek’s disease virus inoculated Chickens, Res. Vet. Sci. 30:243.PubMedGoogle Scholar
  97. Confer, A.W., Adldinger, H.K., and Buening, G.M., 1980, Cell-mediated immunity in Marek’s disease: Correlation of disease-related variables with immune responses in age-resistant Chickens, Am. J. Vet. Res. 41:313.PubMedGoogle Scholar
  98. Cottral, G.E., 1952, The enigma of avian leukosis, Proceedings of the 89th Annual Meeting, Am. Vet. Med. Assoc. 285.Google Scholar
  99. Crittenden, L.B., Muhm, R.L., and Burmester, B.R., 1972, Genetic Control of susceptibility to the avian leukosis Complex. 2. Marek’s disease, Poult. Sci. 51:261.PubMedGoogle Scholar
  100. Dambrine, G., Coudert, F., and Cauchy, L., 1980, Cell-mediated Cytotoxicity in Chickens infected with Marek’s disease virus and the herpesvirus of turkeys, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 320–337, CEC Publication EUR 6470, Luxembourg.Google Scholar
  101. Doak, R.L., Munnell, J.F., and Ragland, W.L., 1973, Ultrastructure of tumor cells in Marek’s disease virus-infected Chickens, Am. J. Vet. Res. 34:1063.PubMedGoogle Scholar
  102. Doi, K., Kojima, A., Akiyama, Y., and Kato, S., 1976, Pathogenicity for Chicks of line cells from lymphoma of Marek’s disease, Natl. Inst. Anim. Health Q. 16:16.Google Scholar
  103. Donahoe, J., Kleven, S., and Eidson, C., 1978, Resistance to Marek’s disease: Effect of Corynebacterium parvum and Marek’s tumor Cell vaccines on tumorigenesis in Chickens, J. Natl. Cancer Inst. 60:829.PubMedGoogle Scholar
  104. Dunn, K.M., and Nazerian, K., 1977, Induction of Marek’s disease virus antigens by IdUrd in a Chicken lymphoblastoid Cell line, J. Gen. Virol. 34:413.PubMedCrossRefGoogle Scholar
  105. Eidson, C.S., and Anderson, D.P., 1971, Immunization against Marek’s disease, Avian Dis. 15:68.PubMedCrossRefGoogle Scholar
  106. Eidson, C.S., and Kleven, S.H., 1977, Application of the Cell-free turkey herpesvirus vaccines by the aerosol route for the prevention of Marek’s disease in Chickens, Poult. Sci. 56:1609.PubMedGoogle Scholar
  107. Eidson, C.S., and Schmittle, S.C., 1968a, Studies on acute Marek’s disease. 1. Characteristics of isolate GA in Chickens, Avian Dis. 12:467.PubMedCrossRefGoogle Scholar
  108. Eidson, C.S., and Schmittle, S.C., 1968b, Studies on acute Marek’s disease. V. Attempted transmission of isolate GA with feces and nasal washings, Avian Dis. 12:549.PubMedCrossRefGoogle Scholar
  109. Eidson, C.S., and Schmittle, S.C., 1969, Studies on acute Marek’s disease. XII. Detection of antibodies with a tannic acid indirect hemagglutination test, Avian Dis. 13:774.PubMedCrossRefGoogle Scholar
  110. Eidson, C.S., Schmittle, S.C., Goode, R.B., and Lai, J.B., 1966, Induction of leukosis tumors with the beetle Alphitobius diaperinus, Am. J. Vet. Res. 27:1053.PubMedGoogle Scholar
  111. Eidson, C.S., Anderson, D.P., Kleven, S.H., and Brown, J., 1971, Field trials of vaccines for Marek’s disease, Avian Dis. 15:312.PubMedCrossRefGoogle Scholar
  112. Eidson, C.S., Villegas, P., Page, R.K., and Kleven, S.H., 1975, A Comparison of the efficacy against Marek’s disease of Cell-free and Cell-associated turkey herpesvirus vaccine, Avian Dis. 19:515.PubMedCrossRefGoogle Scholar
  113. Eidson, C.S., Page, R.K., Giambrone, J.J., and Kleven, S.H., 1976, Long term studies Comparing the efficacy of Cell-free versus Cell-associated HVT vaccines against Marek’s disease, Poult. Sci. 55:1857.PubMedGoogle Scholar
  114. Eidson, C.S., Giambrone, J.J., Fletcher, O.J., and Kleven, S.H., 1980, Vaccination against Marek’s disease with Cell-free herpesvirus of turkeys by aerosol vaccination, Poult. Sci. 59:54.Google Scholar
  115. Eidson, C.S., Ellis, M.N. and Kleven, S.H., 1981, Reduced vaccinal protection of turkey herpesvirus against field strains of Marek’s disease herpesvirus, Poult. Sci. 60:317.PubMedGoogle Scholar
  116. Elmubarak, A.K., Sharma, J.M., Witter, R.L., Nazerian, K. and Sanger, V.L., 1981, Inductions of lymphomas and tumor antigen by Marek’s disease virus in turkeys, Avian Dis. 25:911.PubMedCrossRefGoogle Scholar
  117. Else, R.W., 1974, Vaccinal immunity to Marek’s disease in bursectomised Chickens, Vet. Rec. 95:182.PubMedCrossRefGoogle Scholar
  118. Epstein, M.A., and Achong, B.G. (eds.), 1979, The Epstein-Barr Virus, Springer-Verlag, Berlin, Heidelberg, New York, 459 pp.Google Scholar
  119. Epstein, M.A., Achong, B.G., Churchill, A.E., and Biggs, P.M., 1968, Structure and development of the herpes-type virus of Marek’s disease, J. Natl. Cancer Inst. 41:805.PubMedGoogle Scholar
  120. Evans, D.L., and Patterson, L.T., 1971, Correlation of immunological responsiveness with lymphocyte Changes in Chickens infected with Marek’s disease, Infect. Immun. 4:567.PubMedGoogle Scholar
  121. Evans, D.L., Barnett, J.W., and Dmochowski, L., 1973, Common antigens in herpesviruses from divergent species of animals, Tex. Rep. Biol. Med. 31:756.Google Scholar
  122. Fabricant, C.G., Fabricant, J., Litrenta, M.M., and Minick, C.R., 1978, Virus-induced atherosclerosis, J. Exp. Med. 148:335.PubMedCrossRefGoogle Scholar
  123. Fabricant, J., Ianconescu, M., and Calnek, B.W., 1977, Comparative effects of host and viral factors on early pathogenesis of Marek’s disease, Infect. Immun. 16:136.PubMedGoogle Scholar
  124. Fabricant, J., Calnek, B.W., Schat, K.A., and Murthy, K.K., 1978, Marek’s disease virus-induced tumor transplants in development and rejection in various genetic strains of Chickens, Avian Dis. 22:646.PubMedCrossRefGoogle Scholar
  125. Fauser, I.S., Purchase, H.G., Long, P.A., Velicer, L.F., Mailman, H., Fauser, H.T., and Winegar, CO., 1973, Delayed hypersensitivity and leucocyte migration inhibition in Chickens with BCG or Marek’s disease infection, Avian Pathol. 2:55.PubMedGoogle Scholar
  126. Fernando, W.W.D., and Calnek, B.W., 1971, The influence of the bursa of Fabricius on the infection and pathological response of Chickens exposed to Marek’s disease herpesvirus, Avian Dis. 15:467.PubMedCrossRefGoogle Scholar
  127. Frankel, J.W., Farrow, W.M., Prickett, C.O., Smith, M.E., Campbell, W.F., and Groupé, V., 1974, Responses of isolator-derived and Conventional Chickens to Marek’s disease herpesvirus and avian leukosis virus, J. Natl. Cancer Inst. 52:1491.PubMedGoogle Scholar
  128. Frazier, J.A., 1974, Ultrastructure of lymphoid tissue from Chicks infected with Marek’s disease virus, J. Natl. Cancer Inst. 52:829.PubMedGoogle Scholar
  129. Frazier, J.A., and Powell, P.C., 1975, The ultrastructure of lymphoblastoid Cell lines from Marek’s disease lymphomata, Br. J. Cancer 31:7.PubMedCrossRefGoogle Scholar
  130. Fredericksen, T.L., Longenecker, B.M., Pazderka, F., Gilmour, D.G., and Ruth, R.F., 1977, A T-cell antigen system of Chickens: Ly-4 and Marek’s disease, Immunogenetics 5:535.CrossRefGoogle Scholar
  131. Friars, G.W., Chambers, J.R., Kennedy, A., and Smith, A.D., 1972, Selection for resistance to Marek’s disease in Conjunction with other economic traits in Chickens, Avian Dis. 16:2.PubMedCrossRefGoogle Scholar
  132. Fujimoto, Y., and Okada, K., 1977, Pathological studies of Marek’s disease. III. Electron microscopic observation of demyelination of the peripheral nerves, Jpn. J. Vet. Res. 25:59.PubMedGoogle Scholar
  133. Fujimoto, Y., Nakagawa, M., Okada, K., Okada, M., and Matsukawa, K., 1971, Pathological studies of Marek’s disease. I. The histopathology on field Cases in Japan, Jpn. J. Vet. Res. 19:7.PubMedGoogle Scholar
  134. Fujimoto, Y., Okada, K., Kakihata, K., Matsui, T., Narita, M., Onuma, M., and Mikami, T., 1974, Initial lesions in Chickens infected with JM strain of Marek’s disease virus, Jpn. J. Vet. Res. 22:80.PubMedGoogle Scholar
  135. Gallatin, W.M., and Longenecker, B.M., 1979, Expression of genetic resistance to an oncogenic herpesvirus at the target Cell level, Nature (London) 280:587.CrossRefGoogle Scholar
  136. Gallatin, W.M. and Longenecker, B.M., 1981, Genetic resistance to herpesvirus-induced lymphoma at the level of the target Cell determined by the thymic microenvironment, Int. J. Cancer, 27:373.PubMedCrossRefGoogle Scholar
  137. Gavora, J.S., and Spencer, J.L., 1979, Studies on genetic resistance of Chickens to Marek’s disease—a review, Comp. Immun. Microbiol. Infect. Dis. 2:359.CrossRefGoogle Scholar
  138. Gavora, J.S., Grunder, A.A., Spencer, J.L., Gowe, R.S., Robertson, A., and Speckmann, G.W., 1974, An assessment of effects of vaccination on genetic resistance to Marek’s disease, Poult. Sci. 53:889.PubMedGoogle Scholar
  139. Gavora, J.S., Gowe, R.S., and McAllister, A.J., 1977, Vaccination against Marek’s disease: Efficacy of Cell-associated and lyophilised herpesvirus of turkeys in nine strains of leghorns, Poult. Sci. 56:846.PubMedGoogle Scholar
  140. Giambrone, J.J., Eidson, C.S., Page, K.K., Fletcher, O.J., Barger, B.O., and Kleven, S.H., 1976, Effect of infectious bursal agent on the response of Chickens to Newcastle disease and Marek’s disease vaccination, Avian Dis. 20:534.PubMedCrossRefGoogle Scholar
  141. Goodchild, W.M., 1969, Some observations of Marek’s disease (fowl paralysis), Vet. Rec. 84:87.PubMedCrossRefGoogle Scholar
  142. Goto, N., Fujimoto, Y., Okada, K., Mikami, T., Kodama, H., and Ichijo, K., 1979, Effect of thymectomy on the initial Cytolytic lesions and nerve demyelination of Marek’s disease, Zentralbl. Veterinaermed. Reike B 26:61.CrossRefGoogle Scholar
  143. Gross, W.B., and Colmano, G., 1971, Effect of infectious agents on Chickens selected for plasma Corticosterone response to social stress, Poult. Sci. 50:1213.PubMedGoogle Scholar
  144. Grunder, A.A., Dickerson, G.E., Robertson, A., and Morin, E., 1969, Incidence of Marek’s disease as related to phenotypes of serum alkaline phosphatase, Poult. Sci. 48:1608.PubMedGoogle Scholar
  145. Grunder, A.A., Jeffers, T.K., Spencer, J.L., Robertson, A., and Speckman, G.W., 1972, Resistance of strains of Chickens to Marek’s disease, Can. J. Anim. Sci. 52:1.CrossRefGoogle Scholar
  146. Haffer, K., Sevoian, M., and Wilder, M., 1979, The role of the macrophage in Marek’s disease: In vitro and in vivo studies, Int. J. Cancer 23:648.PubMedCrossRefGoogle Scholar
  147. Hahn, E.C., Ramos, L., and Kenyon, A.J., 1977, Lymphoproliferative diseases of fowl: JM-V leukemic lymphoblasts in Cell Culture (brief Communication), J. Natl. Cancer Inst. 59:267.PubMedGoogle Scholar
  148. Hahn, E.C., Jakowski, R.M., Ramos, L., and Kenyon, A.J., 1978, Lymphoproliferative disease of fowl: Characterization of transplantable G-Bl Marek’s disease tumor cells in Culture, Avian Dis. 22:409.PubMedCrossRefGoogle Scholar
  149. Haider, S.A., Lapen, R.F., and Kenzy, S.G., 1970, Use of feathers in a gel precipitation test for Marek’s disease, Poult. Sci. 69:1654.Google Scholar
  150. Halvorson, D.A., and Mitchell, D.O., 1979, Loss of Cell-associated Marek’s disease vaccine titer during thawing, reconstitution, and use, Avian Dis. 23:848.PubMedCrossRefGoogle Scholar
  151. Hamdy, F., Sevoian, M., and Holt, S.C., 1974, Biogenesis of Marek’s disease (type II leukosis) virus in vitro: Electron microscopy and immunological study, Infect Immun. 9:740.PubMedGoogle Scholar
  152. Han, P.F.-S, and Smyth, J.R., 1972, The influence of growth rate on the development of Marek’s disease in Chickens, Poult Sci. 51:975.PubMedGoogle Scholar
  153. Hansen, M.P., Van Zandt, J.N., and Law, G.R.J., 1967, Differences in susceptibility to Marek’s disease in Chickens Carrying two different B locus blood group alleles, Poult Sci. 46:1268.Google Scholar
  154. Hartmann, W., and Sanz, M., 1970, Resistance to Marek’s disease in broiler strains under natural and artificial exposure, Proc. XIVth World’s Poult Gongr. 3:309.Google Scholar
  155. Hein, M.B., and Mora, E.C., 1980, Distribution of herpesvirus in turkeys, Poult. Sci. 59:494.Google Scholar
  156. Higgins, D.A., and Calnek, B.W., 1975, Fowl immunoglobulins: Quantitation and antibody activity during Marek’s disease in genetically resistant and susceptible birds, Infect. Immun. 11:33.PubMedGoogle Scholar
  157. Higgins, D.A., and Calnek, B.W., 1976, Some effects of silica treatment on Marek’s disease, Infect Immun. 13:1054.PubMedGoogle Scholar
  158. Hinshaw, V.L., and Mora, E.C., 1980, Localization of herpesvirus of turkeys in blood cells, Poult. Sci. 59:258.PubMedGoogle Scholar
  159. Hložánek, I., and Sovova, V., 1974, Lack of pathogenicity of Marek’s disease herpesvirus and herpesvirus of turkeys for mammalian hosts and mammalian Cell Cultures, Folia Biol. (Prague) 20:51.Google Scholar
  160. Hložánek, I., Mach, O., and Jurajda, V., 1973, Cell-free preparations of Marek’s disease virus from poultry dust, Folia Biol. (Prague) 19:118.Google Scholar
  161. Hoffmann-Fezer, G., and Hoffman, R., 1980, Anatomical distribution of T- and B-lympho-cytes in Marek’s disease—an immunohistochemical study, Vet Immunol. Immunopathol. 1:113.PubMedCrossRefGoogle Scholar
  162. Hong, C.C., and Sevoian, M., 1971, Interferon production and host resistance to type II avian (Marek’s) leukosis virus (JM strain), Appl. Microbiol. 22:818.PubMedGoogle Scholar
  163. Hong, C.C., and Sevoian, M., 1972, Comparison of indirect hemagglutination and immunodiffusion tests for detecting type II leukosis (Marek’s) infection in S- and K-line chickens, Appl. Microbiol. 23:449.PubMedGoogle Scholar
  164. Hudson, L., and Payne, L.N.,- 1973, An analysis of the T and B cells of Marek’s disease lymphomas of the Chicken, Nature (London) New Biol. 241:52.CrossRefGoogle Scholar
  165. Ikuta, K., Akiyama, Y., Konobe, T., and Kato, S., 1976a, A lymphoblastoid Cell line dually infected with Marek’s disease virus and avian leukosis virus, Biken J. 19:33.PubMedGoogle Scholar
  166. Ikuta, K., Kato, S., Ando, T., and Konobe, T., 1976b, Lack of expressions of endogenous (gs, chick helper factor) and exogenous avian RNA tumor viruses in the MOB-1 and MSB-1 lines derived from Marek’s disease lymphomas, Biken J. 19:39.PubMedGoogle Scholar
  167. Ikuta, K., Nishi, Y., Kato, S. and Hirai, K., 1981, Immunoprecipitation of Marek’s disease virus-specific polypeptides with Chicken antibodies purified by affinity Chromatography, Virology, 114:277.PubMedCrossRefGoogle Scholar
  168. Inage, F., Kodama, H., and Mikami, T., 1979, Differences between early and late membrane antigens on Cultured cells infected with herpesvirus of turkeys, Avian Pathol. 8:23.PubMedCrossRefGoogle Scholar
  169. Inoue, M., Mikami, T., Kodama, H., Onuma, M., and Izawa, H., 1980, Antigenic differences between intracellular and membrane antigens induced by herpesvirus of turkeys, Arch. Virol. 63:23.PubMedCrossRefGoogle Scholar
  170. Ishikawa, T., Naito, M., Osafune, S., and Kato, S., 1972, Cell surface antigen on quail cells infected with herpesvirus of turkey or Marek’s disease virus, Biken J. 15:215.PubMedGoogle Scholar
  171. Jackson, C.A.W., Biggs, P.M., Bell, R.A., Lancaster, F.M., and Milne, B.S., 1976, The epizootiology of Marek’s disease. 3. The interrelationship of virus pathogenicity, antibody and the incidence of Marek’s disease, Avian Pathol. 5:105.PubMedCrossRefGoogle Scholar
  172. Jakowski, R.M., Fredrickson, T.N., Chomiak, T.W., and Luginbuhl, R.E., 1970, Hematopoietic destruction in Marek’s disease, Avian Dis. 14:374.PubMedCrossRefGoogle Scholar
  173. Jakowski, R.M., Fredrickson, T.N., and Schierman, L.W., 1974, A transplantable lymphoma induced with Marek’s disease virus, J. Natl. Cancer Inst 53:783.PubMedGoogle Scholar
  174. Johnson, E.A., Burke, CN., Fredrickson, T.N., and DiCapua, R.A., 1975, Morphogenesis of Marek’s disease virus in feather follicle epithelium, J. Natl. Cancer Inst. 55:89.PubMedGoogle Scholar
  175. Jurajda, V., and Klimes, B., 1970, Presence and survival of Marek’s disease agent in dust, Avian Dis. 14:188.PubMedCrossRefGoogle Scholar
  176. Kaaden, O.R., Dietzschold, B., and Ueberschar, S., 1974, Vaccination against Marek’s disease: Immunizing effect of purified turkey herpesvirus and Cellular membranes from infected cells, Med. Microbiol. Immunol. (Berlin) 159:261.CrossRefGoogle Scholar
  177. Kaleta, E.F., 1977, Vermehrung, Interferenz und Interferoninduktion aviarer Herpesviru-sarten: Beitrag zur Schutzimpfung gegen die Mareksche Krankheit, Zentralbl. Ve-terinärmed. Reihe B 24:406.CrossRefGoogle Scholar
  178. Kaleta, E.F., and Bankowski, R.A., 1972, Production of interferon by the Cal-1 and turkey herpesvirus strains associated with Marek’s disease, Am. J. Vet. Res. 33:567.PubMedGoogle Scholar
  179. Kaschka-Dierich, C., Thomssen, R., and Nazerian, K., 1979, Studies on the temperature-dependent DNA replication of herpesvirus of the turkey in Chicken embryo fibroblasts, J. Gen. Virol. 45:253.PubMedCrossRefGoogle Scholar
  180. Kato, S., and Akiyama, Y., 1975, Lymphoid Cell lines from lymphomas of Marek’s disease, in: Oncogenesis and Herpesviruses II (G. de Thé, M.A. Epstein, and H. zur Hausen, eds.), pp. 101–108, IARC Scientific Publication No. 11, International Agency for Research on Cancer, Lyon.Google Scholar
  181. Kato, S., Ono, K., Naito, M., Doi, T., Iwa, N., Mori, Y., and Onoda, T., 1970, Isolation of herpes-type virus from Chickens with Marek’s disease using duck embryo fibroblast Cultures, Biken J. 13:193.PubMedGoogle Scholar
  182. Kawamura, H., King, D.J., and Anderson, D.P., 1969, A herpesvirus isolated from kidney Cell Culture of normal turkeys, Avian Dis. 13:853.PubMedCrossRefGoogle Scholar
  183. Kawamura, H., Yamaguchi, S., Matsuda, H., and Kato, S., 1977, Studies on two new lymphoma Cell lines established from Marek’s disease (H. Kawamura, ed.), English Summaries of the Studies on Poultry Diseases in Japan, pp. 8–9, Japanese Veterinary Poultry Association.Google Scholar
  184. Kenzy, S.G., and Biggs, P.M., 1967, Excretion of the Marek’s disease agent by infected Chickens, Vet. Rec. 80:565.Google Scholar
  185. Kenzy, S.G., and Cho, B.R., 1969, Transmission of Classical Marek’s disease by affected and Carrier birds, Avian Dis. 13:211.PubMedCrossRefGoogle Scholar
  186. Kenzy, S.G., Cho, B.R., and Kim, Y., 1973, Oncogenic Marek’s disease herpesvirus in avian encephalitis (temporary paralysis), J. Natl. Cancer Inst. 51:977.PubMedGoogle Scholar
  187. Khare, M.L., Grun, J., and Adams, E.V., 1975, Marek’s disease in Japanese quail—a pathological, virological and serological study, Poult. Sci. 54:2066.PubMedGoogle Scholar
  188. King, D., Page, D., Schat, K.A., and Calnek, B.W., 1981, Differences in influence between homologous and heterologous maternal antibodies on response to serotype-2 and ser-otype-3 Marek’s disease vaccines, Avian Dis. 25:74.PubMedCrossRefGoogle Scholar
  189. Kitamoto, N., Ikuta, K., Kato, S., and Yamaguchi, S., 1979, Cell-mediated Cytotoxicity of lymphocytes from Chickens inoculated with herpesvirus of turkey against a Marek’s disease lymphoma Cell line (MSB-1), Biken J. 22:11.PubMedGoogle Scholar
  190. Kodama, H., Mikami, T., Inoue, M., and Izawa, H., 1979a, Inhibitory effects of macrophages against Marek’s disease virus plaque formation in Chicken kidney Cell Cultures, J. Natl. Cancer Inst. 63:1267.PubMedGoogle Scholar
  191. Kodama, H., Sugimoto, C., Inage, F., and Mikami, T., 1979b, Anti-viral immunity against Marek’s disease virus infected Chicken kidney cells, Avian Pathol. 8:33.PubMedCrossRefGoogle Scholar
  192. Kodama, H., Mikami, T., and Izawa, H., 1980, Effects of levamisole on pathogenesis of Marek’s disease, J. Natl. Cancer Inst. 65:155.PubMedGoogle Scholar
  193. Lam, K.M. and Cho, Y., 1981, In vitro transformation of Chicken lymphocytes with Marek’s disease virus. Proc. Xth International Symposium for Comparative Research on Leukemia and Related Diseases, Los Angeles, 92 (abstract).Google Scholar
  194. Lam, K.M., and Linna, T.J., 1979, Transfer of natural resistance to Marek’s disease (JMV) with non-immune spleen Cells. I. Studies of Cell population transferring resistance, Int. J. Cancer 24:662.PubMedCrossRefGoogle Scholar
  195. Lampert, P., Garrett, R., and Powell, H., 1977, Demyelination in allergic and Marek’s disease virus induced neuritis: Comparative electron microscopic studies, Acta Neuropathol. (Berlin) 40:103.CrossRefGoogle Scholar
  196. Lapen, R.F., Piper, R.C., and Kenzy, S.G., 1970, Cutaneous Changes associated with Marek’s disease of Chickens, J. Natl. Cancer Inst. 45:941.PubMedGoogle Scholar
  197. Lapen, R.F., Kenzy, S.G., Piper, R.C., and Sharma, J.M., 1971, Pathogenesis of Cutaneous Marek’s disease in Chickens, J. Natl. Cancer Inst. 47:389.PubMedGoogle Scholar
  198. Lawn, A.M., and Payne, L.N., 1979, Chronological study of ultrastructural Changes in the peripheral nerves in Marek’s disease, Neuropathol. Appl. Neurobiol. 5:485.PubMedCrossRefGoogle Scholar
  199. Lee, L.F., 1979, Macrophage restriction of Marek’s disease virus replication and lymphoma cell proliferation, J. Immunol. 123:1088.PubMedGoogle Scholar
  200. Lee, L.F., Sharma, J.M., Nazerian, K., and Witter, R.L., 1978a, Suppression and enhancement of mitogen response in Chickens infected with Marek’s disease virus and the herpesvirus of turkeys, Infect. Immun. 21:474.PubMedGoogle Scholar
  201. Lee, L.F., Sharma, J.M., Nazerian, K., and Witter, R.L., 1978b, Suppression of mitogen-induced proliferation of normal spleen cells by macrophages from Chickens inoculated with Marek’s disease virus, J. Immunol. 120:1554.PubMedGoogle Scholar
  202. Lee, L.F., Powell, P.C., Rennie, M., Ross, L.J.N., and Payne, L.N., 1981, Studies on nature of genetic resistance to Marek’s disease in Chickens, J. Natl. Cancer Inst. 66:789.PubMedGoogle Scholar
  203. Lerche, F., and Fritzsche, K., 1934, Histopathologic und Diagnostik der Geflügellahme, Z. Infektsionskr. Hanstiere, 45:89.Google Scholar
  204. Lesnik, F., and Ross, L.J.N., 1975, Immunization against Marek’s disease using Marek’s disease virus-specific antigens free from infectious virus, Int. J. Cancer 16:153.PubMedCrossRefGoogle Scholar
  205. Long, P.A., Clark, J.L., and Velicer, L.E., 1975, Marek’s disease herpesviruses. II. Purification and further Characterization of Marek’s disease herpesvirus A antigen, J. Virol. 15:1192.PubMedGoogle Scholar
  206. Long, P.L., Kenzy, S.G., and Biggs, P.M., 1968, Relationship between Marek’s disease and coccidiosis. I. Attempted transmission of Marek’s disease by avian Coccidia, Vet. Rec. 83:260.PubMedCrossRefGoogle Scholar
  207. Longenecker, B.M., Pazderka, F., Stone, H.S., Gavora, J.S., and Ruth, R.F., 1975, In ovo assay for Marek’s disease virus and turkey herpesvirus, Infect. Immun. 11:922.PubMedGoogle Scholar
  208. Longenecker, B.M., Pazderka, F., Gavora, J.S., Spencer, J.L., and Ruth, R.F., 1976, Lymphoma induced by herpesvirus: Resistance associated with a major histocompatibility gene, Immunogenetics 3:401.CrossRefGoogle Scholar
  209. Longenecker, B.M., Pazderka, F., Gavora, J.S., Spencer, J.L., Stephens, E.A., and Witter, R.L., 1977, Role of the major histocompatibility Complex in resistance to Marek’s disease: Restriction of the growth of JMV-MD tumor cells in genetically resistant birds, Adv. Exp. Med. Biol. 88:287.PubMedGoogle Scholar
  210. Lu, Y.S., and Lapen, R.F., 1974, Splenic Cell mitogenic response in Marek’s disease: Comparison between noninfected tumor-bearing and nontumor-bearing infected Chickens, Am. J. Vet. Res. 35:977.PubMedGoogle Scholar
  211. Marek, J., 1907, Multiple Nervenentzündung bei Hühnen, Dtsch. Tieraerztl. Wochenschr. 15:417.Google Scholar
  212. Marquardt, W.W., and Newman, J.A., 1972, A modified direct Complement-fixation test for detection of Marek’s disease antibodies in Chick serum, Avian Dis. 16:986.CrossRefGoogle Scholar
  213. Matsuda, H., Ikuta, K., Miyamoto, H., and Kato, S., 1976a, Demonstration of Marek’s disease tumor-associated surface antigen (MATSA) on six Cell lines derived from Marek’s disease lymphomas, Biken J. 19:119.PubMedGoogle Scholar
  214. Matsuda, H., Ikuta, K., and Kato, S., 1976b, Detection of T-cell surface determinants in three Marek’s disease lymphoblastoid Cell lines, Biken J. 19:29.PubMedGoogle Scholar
  215. Matthews, R.E.F., 1979, Classification and nomenclature of viruses, Intervirology 12:133.CrossRefGoogle Scholar
  216. Mikami, T., Onuma, M., and Hayashi, T.T.A., 1973, Membrane antigens in arginine-deprived Cultures infected with Marek’s disease herpesvirus, Nature (London) New Biol. 246:211.Google Scholar
  217. Mikami, T., Onuma, M., Hayashi, T.T.A., Narita, M., Okada, K., and Fujimoto, Y., 1975, Pathogenic and serologic studies of Japanese quail infected with JM strain of Marek’s disease herpesvirus, J. Natl. Cancer Inst. 54:607.PubMedGoogle Scholar
  218. Mikami, T., Inoue, M., Kodama, H., Inage, F., Onuma, M., and Izawa, H., 1980a, Relation between the neutralization of herpesvirus of turkeys and the antibody to late-appearing membrane antigen induced by the virus, J. Gen. Virol. 47:221.PubMedCrossRefGoogle Scholar
  219. Mikami, T., Suzuki, K., Kodama, H., Onuma, M., Izawa, H. and Okada, I., 1980b, Antigenic difference between Marek’s disease tumor-associated surface antigens of MSB-1 and RPL-1 Cell lines derived from Marek’s disease lymphoma, in: Viruses in Naturally Occurring Cancers, Cold Spring Harbor Conferences on Cell Proliferation, 7:199.Google Scholar
  220. Minick, C.R., Fabricant, C.G., Fabricant, J., and Litrenta, MM., 1979, Atheroarteriosclerosis induced by infection with a herpesvirus, Am. J. Pathol. 96:673.PubMedGoogle Scholar
  221. Morris, J.R., Ferguson, A.E., and Jerome, F.N., 1970a, Genetic resistance and susceptibility to Marek’s disease, Can. J. Anim. Sci. 50:69.CrossRefGoogle Scholar
  222. Morris, J.R., Ferguson, A.E., and Jerome, F.N., 1970b, Distribution of Marek’s disease lesions in tissues and organs of Columbian Plymouth Rocks selected for resistance and susceptibility to induced Marek’s disease infection, Can. J. Anim. Sci. 50:83.CrossRefGoogle Scholar
  223. Munch, D., Hohlstein, L., and Sevoian, M., 1978, In vitro establishment of Marek’s disease herpesvirus transformed productive and non-productive lymphoblastoid Cell lines, Infect. Immun. 20:315.PubMedGoogle Scholar
  224. Murthy, K.K., and Calnek, B.W., 1978, Pathogenesis of Marek’s disease: Early appearance of Marek’s disease tumor-associated surface antigen in infected Chickens, J. Natl. Cancer Inst. 61:849.PubMedGoogle Scholar
  225. Murthy, K.K., and Calnek, B.W., 1979a, Pathogenesis of Marek’s disease: Effect of immunization with inactivated viral and tumor-associated antigen, Infect. Immun. 26:547.PubMedGoogle Scholar
  226. Murthy, K.K., and Calnek, B.W., 1979b, Marek’s disease tumor-associated surface antigen (MATSA) in resistant versus susceptible Chickens, Avian Dis. 23:831.PubMedCrossRefGoogle Scholar
  227. Murthy, K.K., Dietert, R.R., and Calnek, B.W., 1979, Demonstration of Chicken fetal antigen (CFA) on normal splenic lymphocytes, Marek’s disease lymphoblastoid Cell lines and other neoplasms, Int. J. Cancer 24:349.PubMedCrossRefGoogle Scholar
  228. Naito, M., Ono, K., Doi, T., and Kato, S., 1971, Antibodies in human and monkey sera to herpes-type virus from a Chicken with Marek’s disease and to EB virus detected by the immunofluorescence test, Biken J. 14:161.PubMedGoogle Scholar
  229. Nazerian, K., 1970, Attenuation of Marek’s disease virus and study of its properties in two different Cell Cultures, J. Natl. Cancer Inst. 44:1257.PubMedGoogle Scholar
  230. Nazerian, K., 1971, Further studies on the replication of Marek’s disease virus in the Chicken and in Cell Culture, J. Natl. Cancer Inst. 47:207.PubMedGoogle Scholar
  231. Nazerian, K., 1972, Virology and immunology of Marek’s disease—a review, in: Oncogenesis and Herpesviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 59–73, IARC Scientific Publication No. 2, International Agency for Research on Cancer, Lyon.Google Scholar
  232. Nazerian, K., 1973, Studies on intracellular and membrane antigens induced by Marek’s disease virus, J. Gen. Virol. 21:193.PubMedCrossRefGoogle Scholar
  233. Nazerian, K., 1974, DNA Configuration in the Core of Marek’s disease virus, J. Virol. 13:1148.PubMedGoogle Scholar
  234. Nazerian, K., 1979, Marek’s disease lymphoma of Chicken and its Causative herpesvirus, Biochim. Biophys. Acta 560:375.PubMedGoogle Scholar
  235. Nazerian, K., 1980, Marek’s disease: A herpesvirus-induced malignant lymphoma of the chicken, in: Viral Oncology (G. Klein, ed.), pp. 665–682, Raven Press, New York.Google Scholar
  236. Nazerian, K., and Burmester, B.R., 1968, Electron microscopy of a herpesvirus associated with the agent of Marek’s disease in Cell Culture, Cancer Res. 28:2454.PubMedGoogle Scholar
  237. Nazerian, K., and Chen, J.H., 1973, Immunoferritin studies of Marek’s disease virus directed intracellular and membrane antigens, Arch. Gesainte Virusforsch. 41:59.CrossRefGoogle Scholar
  238. Nazerian, K., and Lee, L.F., 1974, Deoxyribonucleic acid of Marek’s disease virus in a lymphoblastoid Cell line from Marek’s disease tumours, J. Gen. Virol. 25:317.PubMedCrossRefGoogle Scholar
  239. Nazerian, K., and Lee, L.F., 1976, Selective inhibition by phosphonoacetic acid of MDV DNA replication in a lymphoblastoid Cell line, Virology 74:188.PubMedCrossRefGoogle Scholar
  240. Nazerian, K., and Purchase, H.G., 1970, Combined fluorescent antibody and electron microscopy study of Marek’s disease virus infected Cell Culture, J. Virol. 5:79.PubMedGoogle Scholar
  241. Nazerian, K., and Sharma, J.M., 1975, Detection of T-cell surface antigens in a Marek’s disease lymphoblastoid Cell line, J. Natl. Cancel Inst. 54:277.Google Scholar
  242. Nazerian, K., and Witter, R.L., 1970, Cell-free transmission and in vivo replication of Marek’s disease virus, J. Virol. 5:388.PubMedGoogle Scholar
  243. Nazerian, K., Solomon, J.J., Witter, R.L., and Burmester, B.R., 1968, Studies on the etiology of Marek’s disease. II. Finding of a herpesvirus in Cell Culture, Proc. Soc. Exp. Biol. Med. 127:177.PubMedGoogle Scholar
  244. Nazerian, K., Lee, L.F., Witter, R.L., and Burmester, B.R., 1971, Ultrastructural studies of a herpesvirus of turkeys antigenically related to Marek’s disease virus, Virology 43:442.PubMedCrossRefGoogle Scholar
  245. Nazerian, K., Lee, L.F., and Sharma, J.M., 1976, The role of herpesvirus in Marek’s disease lymphoma of Chickens, Prog. Med. Virol. 22:123.PubMedGoogle Scholar
  246. Nazerian, K., Stephens, E.A., Sharma, J.M., Lee, L.F., Gailitis, M., and Witter, R.L., 1977, A nonproducer T lymphoblastoid Cell line from Marek’s disease transplantable tumor (JMV), Avian Dis. 21:69.PubMedCrossRefGoogle Scholar
  247. Nazerian, K., Neiman, P., Okazaki, W., Smith, E.J., and Crittenden, L.B., 1978, Status of endogenous avian RNA tumor virus in Marek’s disease lymphoblastoid Cell lines and susceptibility of those lines to exogenous RNA tumor viruses, Avian Dis. 22:732.PubMedCrossRefGoogle Scholar
  248. Nazerian, K., Elmubarak, A. and Sharma, J.M., 1982, Establishment of B-lymphoblastoid cell lines from Marek’s disease virus-induced tumors in turkeys, Int. J. Cancer, 29:63.PubMedCrossRefGoogle Scholar
  249. Neumann, U., 1980, Lack of serological homology between Chicken alphafoetoprotein, chickenfoetal red blood Cell antigen and Marek’s disease tumour-associated surface antigen, Avian Pathol. 9:597.PubMedCrossRefGoogle Scholar
  250. Okada, I., Yamada, Y., Akiyama, M., Nishimura, I., and Kano, N., 1977, Changes in polymorphic gene frequencies in strains of Chickens selected for resistance to Marek’s disease, Br. Poult. Sci. 18:237.PubMedCrossRefGoogle Scholar
  251. Okada, K., Fujimoto, Y., Mikami, T., and Yonehara, K., 1972, The fine structure of Marek’s disease virus and herpesvirus of turkey in Cell Culture, Jpn. J. Vet. Res. 20:57.PubMedGoogle Scholar
  252. Okada, K., Fujimoto, Y., Nakanishi, Y.H., Onuma, M., and Mikami, T., 1980, Cohelical arrangement of the DNA strain in the Core of Marek’s disease virus particles, Arch. Virol. 64:81.PubMedCrossRefGoogle Scholar
  253. Okazaki, W., Purchase, H.G., and Burmester, B.R., 1970, Protection against Marek’s disease by vaccination with a herpesvirus of turkeys, Avian Dis. 14:413.PubMedCrossRefGoogle Scholar
  254. Okazaki, W., Purchase, H.G., and Burmester, B.R., 1971, The temporal relationship between vaccination with the herpesvirus of turkeys and Challenge with virulent Marek’s disease virus, Avian Dis. 15:753.PubMedCrossRefGoogle Scholar
  255. Okazaki, W., Purchase, H.G., and Burmester, B.R., 1973, Vaccination against Marek’s disease: Possible Causes of failure of herpesvirus of turkeys (strain FC 126) to protect chickens against Marek’s disease, Am. J. Vet. Res. 34:813.PubMedGoogle Scholar
  256. Ono, K., Tanabe, S., Naito, M., Doi, T., and Kato, S., 1970, Antigen Common to a herpes type virus from Chickens with Marek’s disease and EB virus from Burkitt’s lymphoma cells, Biken J. 13:213.PubMedGoogle Scholar
  257. Ono, K., Doi, T., Ishikawa, T., Iwa, N., Naito, M., Kato, S., Koyama, K., Konobe, T., and Takaku, K., 1974, Studies on herpesvirus of turkeys and its virological Characteristics (in Japanese), Jpn. J. Vet. Sci. 36:407.CrossRefGoogle Scholar
  258. Onoda, T., Ono, K., Konobe, T., Naito, M., Mori, Y., and Kato, S., 1970, Propagation of herpes-type virus isolated from Chickens with Marek’s disease in Japanese quail embryo fibroblasts, Biken J. 13:219.PubMedGoogle Scholar
  259. Onuma, M., Mikami, T., and Hayashi, T.T.A., 1974, Properties of the Common antigen associated with Marek’s disease herpesvirus and turkey herpesvirus infections, J. Natl. Cancer Inst. 52:805.PubMedGoogle Scholar
  260. Onuma, M., Mikami, T., Hayashi, T.T.A., Okada, K., and Fujimoto, Y., 1975, Studies of Marek’s disease herpesvirus and turkey herpesvirus specific Common antigen which stimulates the production of neutralizing antibodies, Arch. Virol. 48:85.PubMedCrossRefGoogle Scholar
  261. Onuma, M., Mikami, T., and Hayashi, T.T.A., 1976, Relationship between Common antigen and membrane antigens associated with Marek’s disease herpesvirus and turkey herpesvirus infections, Arch. Virol. 50:305.PubMedCrossRefGoogle Scholar
  262. Pappenheimer, A.M., Dunn, L.C., and Cone, V., 1926, A study of fowl paralysis, Conn. StorrsAgric. Exp. Stn. Bull. 143:186.Google Scholar
  263. Pappenheimer, A.M., Dunn, L.C., and Cone, V., 1929a, Studies on fowl paralysis (neuro-lymphomatosis gallinarum). I. Clinical features and pathology, J. Exp. Med. 49:63.PubMedCrossRefGoogle Scholar
  264. Pappenheimer, A.M., Dunn, L.C., and Seidlin, S.M., 1929b, Studies on fowl paralysis (neu-rolymphomatosis gallinarum). II. Transmission experiments, J. Exp. Med. 49:87.PubMedCrossRefGoogle Scholar
  265. Paterson, J.C., and Cottral, G.E., 1950, Experimental Coronary sclerosis. III. Lymphomatosis as a Cause of Coronary sclerosis in Chickens, Arch. Pathol. 49:699.Google Scholar
  266. Patrascu, I.V., Calnek, B.W., and Smith, M.W., 1972, Vaccination with lyophilized turkey herpesvirus (HVT): Minimum infective and protective doses, Avian Dis. 16:86.PubMedCrossRefGoogle Scholar
  267. Paul, P., Larsen, C.T., Kumar, M.C., and Pomeroy, B.S., 1972, Preliminary observations on egg transmission of turkey herpesvirus (HVT) in turkeys, Avian Dis. 16:27.PubMedCrossRefGoogle Scholar
  268. Payne, L.N., 1970, Immunosuppressive effects of avian oncogenic viruses, Proc. R. Soc. Med. 63:16.PubMedGoogle Scholar
  269. Payne, L.N., 1972, Pathogenesis of Marek’s disease—a review, in: Oncogenesis and Herpesviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 21–37, IARC Scientific Publication No. 2, International Agency for Research on Cancer, Lyon.Google Scholar
  270. Payne, L.N., 1973, Marek’s disease: A possible model for herpesvirus-induced neoplasms in man, in: Analytic and Experimental Epidemiology of Cancer (W. Nakahara, T. Hirayama, K. Nishioka, and H. Sugano, eds.), pp. 235–257, University of Tokyo Press, Tokyo.Google Scholar
  271. Payne, L.N., 1979, Marek’s disease in Comparative medicine, J. R. Soc. Med. 72:635.PubMedGoogle Scholar
  272. Payne, L.N., and Biggs, P.M., 1967, Studies on Marek’s disease. II. Pathogenesis, J. Natl. Cancer Inst. 39:281.PubMedGoogle Scholar
  273. Payne, L.N., and Howes, K., 1980, Lack of beneficial effect of levamisole on Marek’s disease, Avian Pathol. 9:525.PubMedCrossRefGoogle Scholar
  274. Payne, L.N., and Rennie, M., 1970, Lack of effect of bursectomy on Marek’s disease, J. Natl. Cancer Inst. 45:387.PubMedGoogle Scholar
  275. Payne, L.N., and Rennie, M., 1973, Pathogenesis of Marek’s disease in Chicks with and without maternal antibody, J. Natl. Cancer Inst. 51:1559.PubMedGoogle Scholar
  276. Payne, L.N., and Rennie, M., 1976a, The proportions of B and T lymphocytes in lymphomas, peripheral nerves and lymphoid organs in Marek’s disease, Avian Pathol. 5:147.PubMedCrossRefGoogle Scholar
  277. Payne, L.N., and Rennie, M., 1976b, Sequential Changes in the numbers of B and T lymphocytes and other leukocytes in the blood in Marek’s disease, Int. J. Cancer 18:510.PubMedCrossRefGoogle Scholar
  278. Payne, L.N., and Roszkowski, J., 1972, The presence of immunologically uncommitted bursa- and thymus-dependent lymphoid cells in the lymphomas of Marek’s disease, A vi an Pathol. 1:27.Google Scholar
  279. Payne, L.N., Powell, P.C., and Rennie, M., 1975, Response of B and T lymphocyte and other blood leukocytes in Chickens with Marek’s disease, Cold Spring Harbor Symp. Quant. Biol. 39:817.PubMedCrossRefGoogle Scholar
  280. Payne, L.N., Frazier, J.A., and Powell, P.C., 1976, Pathogenesis of Marek’s disease, Int. Rev. Exp. Pathol. 16:59.PubMedGoogle Scholar
  281. Payne, L.N., Rennie, M.C., Powell, P.C., and Rowell, J.G., 1978, Transient effect of Cyclophosphamide on vaccinal immunity to Marek’s disease, Avian Pathol. 7:295.PubMedCrossRefGoogle Scholar
  282. Payne, L.N., Howes, K., Rennie, M., Bumstead, J.M. and Kidd, A.W., 1981, Use of an agar Culture technique for establishing lymphoid Cell lines from Marek’s disease lymphomas, Int. J. Cancer, 28:757.PubMedCrossRefGoogle Scholar
  283. Pazderka, F., Longenecker, B.M., Law, G.R.J., Stone, H.A., and Ruth, R.F., 1975, Histocompatibility of Chicken populations selected for resistance to Marek’s disease, Immuno-genetics 2:93.Google Scholar
  284. Pepose, J.S., Stevens, J.G., Cook, M.L. and Lampert, P.W., 1981, Marek’s disease as a model for the Landry-Guillain-Barré syndrome, Am. J. Pathol. 103:309.PubMedGoogle Scholar
  285. Peters, W.P. Kufe, D., Schlom, J., Frankel, J.W., Prichett, C.O., Groupé, V., and Spiegelman, S., 1973, Biological and biochemical evidence for an interaction between Marek’s disease herpesvirus and avian leukosis virus in vivo, Proc. Natl. Acad. Sci. U.S.A. 70:3175.CrossRefGoogle Scholar
  286. Pevzner, I.Y., Kujdych, I. and Nordskog, A.W., 1981, Immune response and disease resistance in Chickens. II. Marek’s disease and immune response to GAT, Poult. Sci. 60:927.PubMedGoogle Scholar
  287. Phillips, P.A., and Biggs, P.M., 1972, Course of infection in tissues of susceptible Chickens after exposure to strains of Marek;s disease virus and turkey herpesvirus, J. Natl. Cancer Inst. 49:1367.PubMedGoogle Scholar
  288. Powell, P.C., 1975, Immunity to Marek’s disease induced by glutaraldehyde-treated cells of Marek’s disease lymphoblastoid Cell lines, Nature (London) 257:684.CrossRefGoogle Scholar
  289. Powell, P.C., 1976, Studies on Marek’s disease lymphoma-derived Cell lines, Bibl. Haematol. 43:348.Google Scholar
  290. Powell, P.C., 1978, Protection against the JMV Marek’s disease-derived transplantable tumour by Marek’s disease virus-specific antigens, Avian Pathol. 7:305.PubMedCrossRefGoogle Scholar
  291. Powell, P.C., 1980, In vitro stimulation of blood lymphocytes by phytohaemagglutin during the development of Marek’s disease, Avian Pathol. 9:471.PubMedCrossRefGoogle Scholar
  292. Powell, P.C., 1981, Immunity to Marek’s disease, in: Avian Immunology (M.E. Rose, L.N. Payne, and B.M. Freeman, eds.), pp. 263–283, British Poultry Science, Edinburgh.Google Scholar
  293. Powell, P.C., and Rennie, M., 1978, Marek’s disease tumour-specific antigen induced by herpesvirus of turkeys in vaccinated Chickens, Vet. Rec. 103:232.PubMedCrossRefGoogle Scholar
  294. Powell, P.C., and Rennie, M., 1980a, Failure of attenuated Marek’s disease virus and herpesvirus of turkey antigens to protect against the JMV Marek’s disease-derived transplantable tumour, Avian Pathol. 9:193.PubMedCrossRefGoogle Scholar
  295. Powell, P.C., and Rennie, M., 1980b, Marek’s disease tumour-associated surface antigens (MATSA) induced in inoculated Chickens by vaccines against Marek’s disease, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 341–349, CEC Publication EUR 6470, Luxembourg.Google Scholar
  296. Powell, P.C., and Rowell, J.G., 1977, Dissociation of antiviral and antitumor immunity in resistance to Marek’s disease, J. Natl. Cancer Inst. 59:919.PubMedGoogle Scholar
  297. Powell, P.C., Payne, L.N., Frazier, J.A., and Rennie, M., 1974, Tlymphoblastoid Cell lines from Marek’s disease lymphomas, Nature (London) 251:79.CrossRefGoogle Scholar
  298. Powell, P.C., Lawn, A.M., Payne, L.N., Rennie, M., and Ross, L.J.N., 1980a, The effect of virus dose on the development of Marek’s disease in two strains of Chickens, Avian Pathol. 9:567.PubMedCrossRefGoogle Scholar
  299. Powell, P.C., Rennie, M., Ross, L.J.N. and Mustill, B.M., 1980b, The effect of bursectomy on the adoptive transfer of resistance to Marek’s disease, Int. J. Cancer, 26:681.PubMedCrossRefGoogle Scholar
  300. Powell, P.C., Lee, L.F., Mustill, B.M. and Rennie, M., 1982, The mechanism of genetic resistance to Marek’s disease, Int. J. Cancer, 29:169.PubMedCrossRefGoogle Scholar
  301. Prasad, L.B.M., 1978, Induction of delayed hypersensitivity to turkey herpesvirus in fowls, Res. Vet. Sci. 24:258.PubMedGoogle Scholar
  302. Prasad, L.B.M., 1979, Turkey herpesvirus and Marek’s disease virus: A Comparative appraisal, Comp. Immun. Microbiol. Infect. Dis. 2:335.CrossRefGoogle Scholar
  303. Prasad, L.B.M., and Spradbrow, P.B., 1977, Isolation and Characterization of herpesvirus from turkeys, Aust. Vet. J. 53:582.PubMedCrossRefGoogle Scholar
  304. Priester, W.A., and Mason, T.J., 1974, Human Cancer mortality in relation to poultry populations, by County, in 10 south eastern states, J. Natl. Cancer Inst. 53:45.PubMedGoogle Scholar
  305. Prineas, J.W., and Wright, R.G., 1972, The fine structure of peripheral nerve lesions in a virus-induced demyelinating disease in fowl (Marek’s disease), Lab. Invest. 26:548.PubMedGoogle Scholar
  306. Purchase, H.G., 1969, Immunofluorescence in the study of Marek’s disease. 1. Detection of antigen in Cell Culture and an antigenic Comparison of eight isolates, J. Virol. 3:557.PubMedGoogle Scholar
  307. Purchase, H.G., 1970, Virus-specific immunofluorescent and precipitin antigen and Cell-free virus in tissues of birds infected with Marek’s disease, Cancer Res. 30:1898.PubMedGoogle Scholar
  308. Purchase, H.G., 1972, Recent advances in the knowledge of Marek’s disease, Adv. Vet. Sci. Comp. Sci. 16:223.Google Scholar
  309. Purchase, H.G., 1975, Progress in the Control of Marek’s disease, Am. J. Vet. Res. 36:587.PubMedGoogle Scholar
  310. Purchase, H.G., 1976, Prevention of Marek’s disease: A review, Cancer Res. 36:696.PubMedGoogle Scholar
  311. Purchase, H.G., 1977, The etiology and Control of Marek’s disease of Chickens and the economic impact of a successful research program, in: Beltsville Symposia in Agricultural Research, Vol. 1, Virology in Agriculture, pp. 63–81, Allanheld, Osmum, Montclair, New Jersey.Google Scholar
  312. Purchase, H.G., and Biggs, P.M., 1967, Characterization of five isolates of Marek’s disease, Res. Vet. Sci. 8:440.PubMedGoogle Scholar
  313. Purchase, H.G., and Burgoyne, G.H., 1970, Immunofluorescence in the study of Marek’s disease: Detection of antibody, Am. J. Vet. Res. 31:117.PubMedGoogle Scholar
  314. Purchase, H.G., and Sharma, J.M., 1974, Amelioration of Marek’s disease and absence of vaccine protection in immunologically deficient Chicks, Nature (London) 248:419.CrossRefGoogle Scholar
  315. Purchase, H.G., Chubb, R.C., and Biggs, P.M., 1968, Effect of lymphoid leukosis and Marek’s disease on the immunologic responsiveness of the Chicken, J. Natl. Cancer Inst. 40:583.PubMedGoogle Scholar
  316. Purchase, H.G., Burmester, B.R., and Cunningham, C.H., 1971a, Responses of Cell Cultures from various avian species to Marek’s disease virus and herpesvirus of turkeys, Am. J. Vet. Res. 32:1811.PubMedGoogle Scholar
  317. Purchase, H.G., Okazaki, W., and Burmester, B.R., 1971b, Field trials with the herpes virus of turkeys (HVT) strain FC 126 as a vaccine against Marek’s disease, Poult. Sci. 50:775.PubMedGoogle Scholar
  318. Purchase, H.G., Mare, C.F., and Burmester, B.R., 1972a, Antigenic Comparison of avian and mammalian herpesviruses and protection tests against Marek’s disease, Proc. 76th Annu. Meet. U.S. Anim. Health Assoc. 1972:484.Google Scholar
  319. Purchase, H.G., Okazaki, W., and Burmester, B.R., 1972b, The minimum protective dose of the herpesvirus turkeys vaccine against Marek’s disease, Vet. Rec. 91:79.PubMedCrossRefGoogle Scholar
  320. Purchase, H.G., Okazaki, W., and Burmester, B.R., 1972c, Long-term field trials with the herpesvirus of turkeys vaccine against Marek’s disease, Avian Dis. 16:57.PubMedCrossRefGoogle Scholar
  321. Ratz, F., Széky, A., and Ványi, A., 1972, Studies on the histopathologic Changes of acute Marek’s disease, Acta Vet. Acad. Sci. Hung. 22:349.PubMedCrossRefGoogle Scholar
  322. Rennie, M., and Powell, P.C., 1979, Serological Characterisation of Marek’s disease tumour-associated surface antigens on Marek’s disease lymphoma cells and on Cell lines derived from Marek’s disease lymphomas, Avian Pathol. 8:173.PubMedCrossRefGoogle Scholar
  323. Rennie, M., Powell, P.C., and Mustill, B.M., 1980, The effect of bursectomy on vaccination against Marek’s disease with the herpesvirus of turkeys, Avian Pathol. 9:557.PubMedCrossRefGoogle Scholar
  324. Riddell, C., Milne, B.S., and Biggs, P.M., 1978, Herpesvirus of turkey vaccine: Viraemias in field flocks and in experimental Chickens, Vet. Rec. 102:123.PubMedCrossRefGoogle Scholar
  325. Rispens, B.H., von Vloten, H., Mastenbroek, N., Maas, H.J.L., and Schat, K.A., 1972a, Control of Marek’s disease in the Netherlands. I. Isolation of an avirulent Marek’s disease virus (strain CVI 988) and its use in laboratory vaccination trials, Avian Dis. 16:108.PubMedCrossRefGoogle Scholar
  326. Rispens, B.H., von Vloten, H., Mastenbroek, N., Maas, H.J.L., and Schat, K.A., 1972b, Control of Marek’s disease in the Netherlands. II. Field trials on vaccination with an avirulent strain (CVI 988) of Marek’s disease virus, Avian Dis. 16:126.PubMedCrossRefGoogle Scholar
  327. Roizman, B., 1972, The biochemical features of herpesvirus-infected cells, particularly as they relate to their potential oncogenicity—a review, in: Oncogenesis and Herpesviruses (G. de Thé, W. Henle, and F. Rapp, eds.), p. 1079, IARC Scientific Publication No. 2, International Agency for Research on Cancer, Lyon.Google Scholar
  328. Ross, L.J.N., 1977, Antiviral T Cell-mediated immunity in Marek’s disease, Nature (London) 268:644.CrossRefGoogle Scholar
  329. Ross, L.J.N., 1980, Mechanism of protection Conferred by HVT, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 289–297, CEC Publication EUR 6470, Luxembourg.Google Scholar
  330. Ross, L.J.N., Biggs, P.M., and Newton, A.A., 1973, Purification and properties of the “A” antigen associated with Marek’s disease virus infections, J. Gen. Virol. 18:291.PubMedCrossRefGoogle Scholar
  331. Ross, L.J.N., Powell, P.C., Walker, D.J., Rennie, M., and Payne, L.N., 1977, Expression of virus-specific, thymus-specific and tumour-specific antigens in lymphoblastoid Cell lines derived from Marek’s disease lymphomas, J. Gen. Virol. 35:219.PubMedCrossRefGoogle Scholar
  332. Ross, L.J.N., DeLorbe, W., Varmus, H.E., Bishop, J.M., Brahic, M. and Haase, A., 1981, Persistence and expression of Marek’s disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization, J. Gen. Virol. 57:285.PubMedCrossRefGoogle Scholar
  333. Rouse, B.T., Wells, R.J.H., and Warner, M.L., 1973, Proportion of T and B lymphocytes in lesion of Marek’s disease: Theoretical implications for pathogenesis, J. Immunol. 110:534.PubMedGoogle Scholar
  334. Schat, K.A., 1981, Role of the spleen in the pathogenesis of Marek’s disease, Avian Pathol. 10:171.PubMedCrossRefGoogle Scholar
  335. Schat, K.A., and Calnek, B.W., 1978a, Characterization of an apparently nononcogenic Marek’s disease virus, J. Natl. Cancer Inst. 60:1075.PubMedGoogle Scholar
  336. Schat, K.A., and Calnek, B.W., 1978b, In vitro inactivation of Cell-free Marek’s disease herpesvirus by immune peripheral blood lymphocytes, Avian Dis. 22:693.PubMedCrossRefGoogle Scholar
  337. Schat, K.A., and Calnek, B.W., 1978c, Protection against Marek’s disease-derived tumor transplants by the non-oncogenic SB-1 strain of Marek’s disease virus, Infect. Immun. 22:225.PubMedGoogle Scholar
  338. Schat, K.A., and Calnek, B.W., 1978d, Demonstration of Marek’s disease tumour-associated surface antigen in Chickens infected with nononcogenic Marek’s disease virus and herpesvirus of turkeys, J. Natl. Cancer Inst. 61:855.PubMedGoogle Scholar
  339. Schat, K.A., and Calnek, B.W., 1980, In vitro Cytotoxicity of spleen lymphocytes against Marek’s disease tumour Cells: Induction by SB-1, an apparently non-oncogenic Marek’s disease virus, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 301–316, CEC Publication EUR 6470, Luxembourg.Google Scholar
  340. Schat, K.A., and Murthy, K.K., 1980, In vitro Cytotoxicity against Marek’s disease lymphoblastoid Cell lines after enzymatic removal of Marek’s disease tumor associated surface antigen, J. Virol. 34:130.PubMedGoogle Scholar
  341. Schat, K.A., Schultsz, R.D., and Calnek, B.W., 1978, Marek’s disease: Effect of virus pathogenicity and genetic susceptibility on responses of peripheral blood lymphocytes to concanavalin-A, in: Advances in Comparative Leukemia Research (P. Benvelzen, J. Hilgers, and D.S. Yohn, eds.), pp. 183–186, Elsevier/North-Holland, Amsterdam.Google Scholar
  342. Schat, K.A., Calnek, B.W. and Fabricant, J., 1981, Influence of the bursa of Fabricius on the pathogenesis of Marek’s disease, Infect Immun. 31:199.PubMedGoogle Scholar
  343. Schidlovsky, G., Ahmed, M., and Jensen, K.E., 1969, Herpesvirus in Marek’s disease tumors, Science 164:959.PubMedCrossRefGoogle Scholar
  344. Schierman, L.W., and Fletcher, O.J., 1980, Genetic Control of Marek’s disease virus-induced transient paralysis: Association with the major histocompatibility Complex, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 429–440, CEC Publication EUR 6470, Luxembourg.Google Scholar
  345. Schierman, L.W., Theis, G.A., and McBride, R.A., 1976, Preservation of a T Cell-mediated immune response in Marek’s disease virus-infected Chickens by vaccination with a related virus, J. Immunol. 116:1497.PubMedGoogle Scholar
  346. Schmahl, W., Hoffman-Fezer, G., and Hoffman, R., 1975, Zur Pathogenese der Nervenläsionen bei Marekscher Krankheit des Huhnes. I. Allergische Lantreaktion gegen Myelin peripherer Nerven, Z. Immuntaetsorsch. Exp. Ther. 150:175.Google Scholar
  347. Schmittle, S.C., and Edison, C.S., 1968, Studies on acute Marek’s disease. IV. Relative susceptibility of different lines and Crosses of Chickens to GA isolate, Avian Dis. 12:571.PubMedCrossRefGoogle Scholar
  348. Sekiya, Y., Sakata, M., Mima, K., Namiki, T., Yoshizawa, A., and Chikatisune, M., 1977, Properties of JMV Marek’s disease tumour cells (JMV-S), (H. Kawamura, ed.), English Summaries of the Studies on Poultry Diseases in Japan, p. 10, Japanese Veterinary Poultry Association.Google Scholar
  349. Sevoian, M., 1968, Egg transmission studies of type II leukosis infection (Marek’s disease), Poult. Sci. 47:1644.PubMedGoogle Scholar
  350. Sevoian, M., Chamberlain, D.M., and Counter, F.T., 1962, Avian lymphomatosis. I. Experimental reproduction of the neural and visceral forms, Vet. Med. 57:500.Google Scholar
  351. Sevoian, M., Chamberlain, D.M., and Larose, R.N., 1963, Avian lymphomatosis. V. Airborne transmission, Avian Dis. 7:102.PubMedCrossRefGoogle Scholar
  352. Sevoian, M., Larose, R.N., and Chamberlain, D.M., 1964, Avian lymphomatosis: Increased pathogenicity of JM virus, Proc. 101st Annu. Meet. Am. Vet. Med. Assoc. 342.Google Scholar
  353. Sharma, J.M., 1974, Resistance to Marek’s disease in immunologically deficient Chickens, Nature (London) 247:117.CrossRefGoogle Scholar
  354. Sharma, J.M., 1975, Marek’s disease, in: Isolation and Identification of Avian Pathogens (S.B. Hitchner, CH. Domermuth, H.G. Purchase, and J.E. Williams, eds.), pp. 235–250, Arnold Printing, Ithaca, New York.Google Scholar
  355. Sharma, J.M., 1977, Cell-mediated immunity to tumor antigen in Marek’s disease: Susceptibility of effector cells to antithymocyte serum and enhancement of Cytotoxic activity by Vibrio Cholerae neuraminidase, Infect. Immun. 18:46.PubMedGoogle Scholar
  356. Sharma, J.M., 1978, Immunopathology of Marek’s disease, in: Animal Models of Comparative and Developmental Aspects of Immunity and Disease (M.E. Gershwin and E.L. Cooper, eds.), pp. 132–142, Peramon Press, Oxford.Google Scholar
  357. Sharma, J.M., 1979, Immunosuppressive effects of lymphoproliferative neoplasms of Chickens, Avian Dis. 23:315.CrossRefGoogle Scholar
  358. Sharma, J.M., 1980, In vitro suppression of T-cell mitogenic response and tumor Cell proliferation by spleen macrophages from normal Chickens, Infect. Immun. 28:914.PubMedGoogle Scholar
  359. Sharma, J.M., 1981a, Fractionation of Marek’s disease virus induced lymphoma by velocity sedimentation and association of infectivity with Cellular functions with and without tumor antigen expression, Am. J. Vet. Res. 42:483.PubMedGoogle Scholar
  360. Sharma, J.M., 1981b, Natural killer Cell activity in Chickens exposed to Marek’s disease virus: inhibition of activity in susceptible Chickens and enhancement of activity in resistant and vaccinated Chickens, Avian Dis. 25:882.PubMedCrossRefGoogle Scholar
  361. Sharma, J.M. and Burmester, B.R., 1982, Resistance to Marek’s disease at hatching in Chickens vaccinated as embryos with the turkeys herpesvirus, Avian Dis. 26:134.PubMedCrossRefGoogle Scholar
  362. Sharma, J.M., and Coulson, B.D., 1977, Cell-mediated Cytotoxic response to cells bearing Marek’s disease tumor-associated surface antigen in Chickens infected with Marek’s disease virus, J. Natl. Cancer Inst. 58:1647.PubMedGoogle Scholar
  363. Sharma, J.M., and Coulson, B.D., 1980, Natural immunity against Marek’s disease tumour Cells: Cytotoxicity of spleen cells from specific pathogen free Chickens against MSB-1 target cells, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 223–229, CEC Publication EUR 6470, Luxembourg.Google Scholar
  364. Sharma, J.M., and Purchase, H.G., 1974, Replication of Marek’s disease virus in Cell Cultures derived from genetically resistant Chickens, Infect. Immun. 9:1092.PubMedGoogle Scholar
  365. Sharma, J.M., and Stone, H.A., 1972, Genetic resistance to Marek’s disease: Delineation of the response of genetically resistant Chickens to Marek’s disease virus infection, Avian Dis. 16:894.PubMedCrossRefGoogle Scholar
  366. Sharma, J.M., and Witter, R.L., 1975, The effect of B-cell immunosuppression on age-related resistance of Chickens to Marek’s disease, Cancer Res. 35:711.PubMedGoogle Scholar
  367. Sharma, J.M., Kenzy, S.G., and Rissberger, A., 1969, Propagation and behaviour in Chicken kidney Cultures of the agent associated with Classical Marek’s disease, J. Natl. Cancer Inst. 43:907.PubMedGoogle Scholar
  368. Sharma, J.M., Davis, W.C., and Kenzy, S.G., 1970, Etiologic relationship of skin tumors (skin leukosis) of Chickens to Marek’s disease, J. Natl. Cancer Inst. 44:901.PubMedGoogle Scholar
  369. Sharma, J.M., Witter, R.L., Shramek, G., Wolfe, L.G., Burmester, B.R., and Deinhardt, F., 1972, Lack of pathogenicity of Marek’s disease virus and herpesvirus of turkeys in marmoset monkeys, J. Natl. Cancer Inst. 49:1191.PubMedGoogle Scholar
  370. Sharma, J.M., Witter, R.L., Burmester, B.R., and Landon, J.C., 1973a, Public health implications of Marek’s disease virus and herpesvirus of turkeys: Studies on human and subhuman primates, J. Natl. Cancer Inst. 51:1123.PubMedGoogle Scholar
  371. Sharma, J.M., Witter, R.L., and Burmester, B.R., 1973b, Pathogenesis of Marek’s disease in old Chickens: Lesion regression as the basis for age-related resistance, Infect. Immun. 8:715.PubMedGoogle Scholar
  372. Sharma, J.M., Witter, R.L., and Purchase, H.G., 1975, Absence of age resistance in neonatally thymectomized Chickens as evidence for Cell-mediated immune surveillance in Marek’s disease, Nature (London) 253:477.CrossRefGoogle Scholar
  373. Sharma, J.M., Coulson, B.D., and Young, E., 1976, Effect of in vitro adaptation of Marek’s disease virus on pock induction on the Chorioallantoic membrane of embryonated Chicken eggs, Infect. Immun. 13:292.PubMedGoogle Scholar
  374. Sharma, J.M., Nazerian, K., and Witter, R.L., 1977, Reduced incidence of Marek’s disease gross lymphomas in T-cell-depleted Chickens, J. Natl. Cancer Inst. 58:689.PubMedGoogle Scholar
  375. Sharma, J.M., Witter, R.L., and Coulson, B.D., 1978, Development of Cell-mediated immunity to Marek’s disease tumor cells in Chicks inoculated with Marek’s disease vaccines, J. Natl. Cancer Inst. 61:1273.PubMedGoogle Scholar
  376. Sharma, J.M., Lee, L.F., and Witter, R.L., 1980, Effect of neonatal thymectomy on pathogenesis of herpesvirus of turkeys in Chickens, Am. J. Vet. Res. 40:761.Google Scholar
  377. Shearman, P.J., and Longenecker, B.M., 1980, Selection for virulence and organ-specific metastasis of herpesvirus-transformed lymphoma cells, Int. J. Cancer 25:363.PubMedCrossRefGoogle Scholar
  378. Shearman, P.J. and Longenecker, B.M., 1981, Clonal variation and functional Correlation of organ-specific metastasis and an organ-specific metastasis-associated antigen, Int. J. Cancer 27:387.PubMedCrossRefGoogle Scholar
  379. Shearman, P.J., Gallatin, W.M., and Longenecker, B.M., 1980, Detection of a Cell-surface antigen Correlated with organ-specific metastasis, Nature (London) 286:267.CrossRefGoogle Scholar
  380. Shieh, H.K., and Sevoian, M., 1974, Antibody response of susceptible and resistant Chickens (type II leukosis) infected with JM and JM-V leukosis strains and herpesvirus of turkeys (HVT), Avian Dis. 18:318.PubMedCrossRefGoogle Scholar
  381. Shieh, H.K., and Sevoian, M., 1978, The influence of humoral and Cellular immune system on Chickens with Marek’s disease, J. Chinese Vet. Sci. 4:3.Google Scholar
  382. Siegmann, O., Kaleta, E.F., and Schindler, P., 1980, Short- and long-term stability studies on four lyophilized and one Cell-associated turkey herpesvirus vaccines against Marek’s disease of Chickens, Avian Pathol. 9:21.PubMedCrossRefGoogle Scholar
  383. Smith, M.E., Campbell, W.F., Farrow, W.M., and Frankel, J.W., 1975, Enhancement and interference in Chickens inoculated with Marek’s disease herpesvirus and oncornaviruses, Proc. Soc. Exp. Biol. Med. 150:574.PubMedGoogle Scholar
  384. Smith, M.W., and Calnek, B.W., 1973, Effect of virus pathogenicity on antibody production in Marek’s disease, Avian Dis. 17:727.PubMedCrossRefGoogle Scholar
  385. Smith, M.W., and Calnek, B.W., 1974, Comparative features of low-virulence and high-virulence Marek’s disease virus infections, Avian Pathol. 3:229.PubMedGoogle Scholar
  386. Smith, T.W., Albert, D.M., Robinson, N., Calnek, B.W., and Schwabe, O., 1974, Ocular manifestations of Marek’s disease, Invest. Ophthalmol. 13:586.PubMedGoogle Scholar
  387. Solomon, J.J., and Witter, R.L., 1973, Absence of Marek’s disease in Chicks hatched from eggs Containing blood or meat spots, Avian Dis. 17:141.PubMedCrossRefGoogle Scholar
  388. Solomon, J.J., Witter, R.L., Nazerian, K., and Burmester, B.R., 1968, Studies on the etiology of Marek’s disease. I. Propagation of the agent in Cell Culture, Proc. Soc. Exp. Biol. Med. 127:173.PubMedGoogle Scholar
  389. Solomon, J.J., Witter, R.L., Stone, H.A., and Champion, L.R., 1970, Evidence against embryo transmission of Marek’s disease virus, Avian Dis. 14:752.PubMedCrossRefGoogle Scholar
  390. Spencer, J.L., 1969, Marek’s disease herpesvirus: In vivo and in vitro infection of kidney cells of different genetic strains, Avian Dis. 13:753.PubMedCrossRefGoogle Scholar
  391. Spencer, J.L., and Calnek, B.W., 1967, Storage of cells infected with Rous sarcoma virus or JM strain avian lymphomatosis agent, Avian Dis. 11:274.CrossRefGoogle Scholar
  392. Spencer, J.L., and Gavora, J.S., 1980, Influence of genotype of Chickens and immune status of dams on response to vaccination with turkey herpesvirus, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 519–535, CEC Publication EUR 6470, Luxembourg.Google Scholar
  393. Spencer, J.L., and Robertson, A., 1972, Influence of maternal antibody on infection with virulent or attenuated Marek’s disease herpesvirus, Am. J. Vet. Res. 33:393.PubMedGoogle Scholar
  394. Spencer, J.L., Grunder, A.A., Robertson, A., and Speckmann, G.W., 1972, Attenuated Marek’s disease herpesvirus: Protection Conferred on strains of Chickens varying in genetic resistance, Avian Dis. 16:94.PubMedCrossRefGoogle Scholar
  395. Spencer, J.L., Gavora, J.S., Grunder, A.A., Robertson, A., and Speckmann, G.W., 1974, Immunization against Marek’s disease: Influence of strain of Chickens, maternal antibody and type of vaccine, Avian Dis. 18:33.PubMedCrossRefGoogle Scholar
  396. Spencer, J.L., Gavora, J.S., Hare, W.C.D., Grunder, A.A., Robertson, A., and Speckmann, G.W., 1976, Studies on genetic resistance and on vaccination-induced resistance of Chickens to lymphoid tumor transplants. I. Marek’s disease tumor transplant (JMV), Avian Dis. 20:268.PubMedCrossRefGoogle Scholar
  397. Stephens, E.A., Witter, R.L., Lee, L.F., Sharma, J.M., Nazerian, K., and Longenecker, B.M., 1976, Characteristics of JMV Marek’s disease tumor: A non-productively infected transplantable Cell lacking in rescuable virus, J. Natl. Cancer Inst. 57:865.PubMedGoogle Scholar
  398. Stephens, E.A., Witter, R.L., Nazerian K., and Sharma, J.M., 1980, Development and Characterization of a Marek’s disease transplantable tumor in inbred, line 72 Chickens homozygous at the major (B) histocompatibility locus, Avian Dis. 24:358.PubMedCrossRefGoogle Scholar
  399. Stevens, J.G., Pepose, J.S. and Cook, M.L., 1981, Marek’s disease: A natural model for the Landry-Guillain-Barré syndrome, Ann. Neurol, suppl. 9:102.PubMedCrossRefGoogle Scholar
  400. Stone, H.A., 1975, Use of highly inbred Chickens in research, Agric. Res. Serv. U.S. Dept. Agric. Tech. Bull. 1514:22.Google Scholar
  401. Stone, H.A., Holly, E.A., Burmester, B.R., and Coleman, T.H., 1970, Genetic Control of Marek’s disease, Poult. Sci. 49:1441.Google Scholar
  402. Sugimoto, C., Kodama, H., and Mikami, T., 1978, Anti-tumor immunity against Marek’s disease-derived lymphoblastoid Cell line (MSB-1), Jpn. J. Vet. Res. 26:57.PubMedGoogle Scholar
  403. Sugiyama, M., Hagiwara, S., Ichinose, M., Horiuchi, T., and Isoda, M., 1973, Pathological Changes of spontaneous Cases of Marek’s disease. I. Lesions Classified by location in the peripheral and Central nervous system, Bull. Nippon Vet. Zootech. Coll. (Nihon Jui Chikusan Daigaku Kiyo) 22:9.Google Scholar
  404. Takagi, N., Sasaki, M., Ikuta, K., and Kato, S., 1977, Chromosomal Characteristics of six Cultured lymphoblastoid Cell lines originating from Marek’s disease lymphomas, Biken J. 20:21.PubMedGoogle Scholar
  405. Tanaka, A., Joel, M., Silver, S., and Nonoyama, N., 1978, Biochemical evidence of the nonintegrated status of Marek’s disease virus DNA in virus-transformed lymphoblastoid cells of Chicken, Virology 88:19.PubMedCrossRefGoogle Scholar
  406. Theis, G.A., 1977, Effects of lymphocytes from Marek’s disease infected Chickens on mi-togenic responses of syngeneic normal Chicken spleen cells, J. Immunol. 118:887.PubMedGoogle Scholar
  407. Theis, G.A., 1979, Immune reactivity in Marek’s disease during viral oncogenesis and protective vaccination, in: Immune Mechanisms and Disease (D.B. Amos, R.S. Schwartz, and B.W. Janicki, eds.), pp. 323–338, Academic Press, New York.Google Scholar
  408. Theis, G.A., 1981, Subpopulations of suppressor cells in Chickens infected with cells of a transplantable lymphoblastic leukemia, Infect. Immun. 34:526.PubMedGoogle Scholar
  409. Theis, G.A., Schierman, L.W., and McBride, R.A., 1974, Transplantation of a Marek’s disease lymphoma in syngeneic Chickens, J. Immunol. 113:1710.PubMedGoogle Scholar
  410. Thompson, D.L., Elgert, K.D., Gross, W.B., and Siegel, P.B., 1980, Cell-mediated immunity in Marek’s disease virus-infected Chickens genetically selected for high and low Concentrations of plasma Corticosterone, Am. J. Vet. Res. 41:91.PubMedGoogle Scholar
  411. Thornton, D.H., Hinton, M.H., and Muskett, J.C., 1975, Efficacy of Marek’s disease vaccines: Protection and viraemia studies with turkey herpes virus vaccines, Avian Pathol. 4:97.PubMedGoogle Scholar
  412. Thurston, R.J., Hess, R.A., Biellier, H.V., Adldinger, H.K., and Solorzano, R.F., 1975, Ultra-structural studies of semen abnormalities and herpesvirus associated with Cultured testicular cells from domestic turkeys, J. Reprod. Fertil. 45:235.PubMedCrossRefGoogle Scholar
  413. Velicer, L.F., Yager, D.R., and Clark, J.L., 1978, Marek’s disease herpesvirus. III. Purification and Characterization of Marek’s disease herpesvirus B antigen, J. Virol. 27:205.PubMedGoogle Scholar
  414. Vengris, V.E., and Mare, C.J., 1973, Protection of Chickens against Marek’s disease virus JM-V strain with statolon and exogenous interferon, Avian Dis. 17:758.PubMedCrossRefGoogle Scholar
  415. Von Krosigk, C.M., McClary, C.F., Vielitz, E., and Zander, D.V., 1972, Selection for resistance to Marek’s disease and its expected effects on other important traits in White Leghorn Strain Crosses, Avian Dis. 16:11.CrossRefGoogle Scholar
  416. Wainberg, M.A., Beiss, B., and Israel, E., 1980, Virus-mediated abrogation of Chicken lymphocyte responsiveness to mitogenic stimulus, Avian Dis. 24:580.PubMedCrossRefGoogle Scholar
  417. Washburn, K.W., Eidson, C.S., and Lowe, R.H., 1971, Association of hemoglobulin type with resistance to Marek’s disease, Poult Sci. 50:90.PubMedGoogle Scholar
  418. Waters, N.F., 1951, Mortality from lymphomatosis and other Causes among inbred lines of White Leghorns, Poult. Sci. 30:531.Google Scholar
  419. Weiss, R.A., and Biggs, P.M., 1972, Leukosis and Marek’s disease viruses of feral Red Jungle Fowl and domestic fowl in Malaya. J. Natl. Cancer Inst. 49:1713.PubMedGoogle Scholar
  420. Wight, P.A.L., 1962a, Variations in peripheral nerve histopathology in fowl paralysis, J. Comp. Pathol. 72:40.PubMedGoogle Scholar
  421. Wight, P.A.L., 1962b, The histopathology of the Central nervous system in fowl paralysis, J. Comp. Pathol. 72:348.PubMedGoogle Scholar
  422. Wight, P.A.L., 1966, Histopathology of the skeletal muscles in fowl paralysis (Marek’s disease), J. Comp. Pathol. 76:333.PubMedCrossRefGoogle Scholar
  423. Wight, P.A.L., 1968, The histopathology of transient paralysis of the domestic fowl, Vet. Rec. 82:749.Google Scholar
  424. Wight, P.A.L., 1969, The ultrastructure of sciatic nerves affected by fowl paralysis (Marek’s disease), J. Comp. Pathol. 79:563.PubMedCrossRefGoogle Scholar
  425. Withell, J., 1973, A focus forming technique for the assay of HVT vaccines against Marek’s disease, Dev. Biol. Stand. 25:287.Google Scholar
  426. Witter, R.L., 1971, Marek’s disease research—History and perspectives, Poult. Sci. 50:333.PubMedGoogle Scholar
  427. Witter, R.L., 1972, Turkey herpesvirus: Lack of oncogenicity for turkeys, Avian Dis. 16:666.PubMedCrossRefGoogle Scholar
  428. Witter, R.L., 1976, Natural mechanisms of Controlling lymphotropic herpesvirus infection (Marek’s disease) in the Chicken, Cancer Res. 36:681.PubMedGoogle Scholar
  429. Witter, R.L., 1982, Protection by attenuated and polyvalent vaccines against highly virulent strains of Marek’s disease virus, Avian Pathol, 11:49.PubMedCrossRefGoogle Scholar
  430. Witter, R.L., and Burmester, B.R., 1967, Transmission of Marek’s disease with oral washings and feces from infected Chickens, Proc. Soc. Exp. Biol. Med. 124:59.PubMedGoogle Scholar
  431. Witter, R.L., and Burmester, B.R., 1979, Differential effect of maternal antibodies on efficacy of Cellular and Cell-free Marek’s disease vaccines, Avian Pathol. 8:145.PubMedCrossRefGoogle Scholar
  432. Witter, R.L., and Fadly, A.M., 1980, Characteristics of some selected Marek’s disease virus field isolates, in: Resistance and Immunity to Marek’s Disease (P.M. Biggs, ed.), pp. 181–191, CEC Publication EUR 6470, Luxembourg.Google Scholar
  433. Witter, R.L., and Offenbecker, L., 1978, Duration of vaccinal immunity against Marek’s disease, Avian Dis. 22:396.PubMedCrossRefGoogle Scholar
  434. Witter, R.L., and Offenbecker, L., 1979, Non-protective and temperature-sensitive variants of Marek’s disease vaccine viruses, J. Natl. Cancer Inst. 62:143.PubMedGoogle Scholar
  435. Witter, R.L., and Sharma, J.M., 1974, Transient infectivity and heterokaryon formation in hamster Cell Cultures inoculated with Cell-associated stocks of Marek’s disease virus and herpesvirus of turkeys, J. Natl. Cancer Inst. 53:1731.PubMedGoogle Scholar
  436. Witter, R.L., and Solomon, J.J., 1971, Epidemiology of a herpesvirus of turkeys: Possible sources and spread of infection in turkey flocks, Infect. Immun. 4:356.PubMedGoogle Scholar
  437. Witter, R.L., and Solomon, J.J., 1972, Experimental infection of turkeys and Chickens with a herpesvirus of turkeys (HVT), Avian Dis. 16:34.PubMedCrossRefGoogle Scholar
  438. Witter, R.L., Burgoyne, G.H., and Burmester, B.R., 1968, Survival of Marek’s disease agent in litter and droppings, Avian Dis. 12:522.PubMedCrossRefGoogle Scholar
  439. Witter, R.L., Solomon, J.J., and Burgoyne, G.H., 1969, Cell Culture techniques for primary isolation of Marek’s disease-associated herpesvirus, Avian Dis. 13:101.PubMedCrossRefGoogle Scholar
  440. Witter, R.L., Moulthrop, J.I., Burgoyne, G.H., and Connell, H.C., 1970a, Studies on the epidemiology of Marek’s disease herpesvirus in broiler flocks, Avian Dis. 14:255.PubMedCrossRefGoogle Scholar
  441. Witter, R.L., Nazerian, K., Purchase, H., and Burgoyne, G.H., 1970b, Isolation from turkeys of a Cell-associated herpesvirus antigenically related to Marek’s disease virus, Am. J. Vet. Res. 31:525.PubMedGoogle Scholar
  442. Witter, R.L., Purchase, H.G., and Burgoyne, G.H., 1970c, Peripheral nerve lesions similar to those of Marek’s disease in Chickens inoculated with reticuloendotheliosis virus, J. Natl. Cancer Inst. 45:567.PubMedGoogle Scholar
  443. Witter, R.L., Solomon, J.J., Champion, L.R., and Nazerian, K., 1971, Long-term studies of Marek’s disease infection in individual Chickens, Avian Dis. 15:346.PubMedCrossRefGoogle Scholar
  444. Witter, R.L., Nazerian, K., and Solomon, J.J., 1972, Studies on the in vivo replication of turkey herpesvirus, J. Natl. Cancer Inst. 49:1121.PubMedGoogle Scholar
  445. Witter, R.L., Sharma, J.M., Solomon, J.J., and Champion, L.R., 1973, An age-related resistance of Chickens to Marek’s disease: Some preliminary observations, Avian Pathol. 2:43.PubMedGoogle Scholar
  446. Witter, R.L., Solomon, J.J., and Sharma, J.M., 1974, Response of turkeys to infection with virulent Marek’s disease viruses of turkey and Chicken origins, Am. J. Vet. Res. 35:1325.PubMedGoogle Scholar
  447. Witter, R.L., Lee, L.F., Okazaki, W., Purchase, H.G., Burmester, B.R., and Luginbuhl, R.E., 1975a, Oncogenesis by Marek’s disease herpesvirus in Chickens lacking expression of endogenous (gs, Chick helper factor, Rous-associated virus—O) and exogenous avian RNA tumor viruses, J. Natl. Cancer Inst. 55:215.PubMedGoogle Scholar
  448. Witter, R.L., Stephens, E.A., Sharma, J.M., and Nazerian, K., 1975b, Demonstration of a tumor-associated surface antigen in Marek’s disease, J. Immunol. 115:177.PubMedGoogle Scholar
  449. Witter, R.L., Sharma, J.M., and Offenbecker, L., 1976, Turkey herpesvirus infection in chickens: Induction of lymphoproliferative lesions and Characterization of vaccinal immunity against Marek’s disease, Avian Dis. 20:676.PubMedCrossRefGoogle Scholar
  450. Witter, R.L., Kato, S., Calnek, B.W., Powell, P.C., et al., 1979, A proposed method for designating avian Cell lines and transplantable tumours, Avian Pathol. 8:487.CrossRefGoogle Scholar
  451. Witter, R.L., Sharma, J.M., and Fadly, A.M., 1980, Pathogenicity of variant Marek’s disease virus isolants in vaccinated and unvaccinated Chickens, Avian Dis. 24:210.CrossRefGoogle Scholar
  452. Wyn-Jones, A.P., and Kaaden, O.-R., 1979, Induction of virus-neutralising antibody by glycoproteins isolated from chicken cells infected with a herpesvirus of turkeys, Infect. Immun. 25:54.PubMedGoogle Scholar
  453. Yoshida, I., Yuasa, N., Horiuchi, T., and Tsubahara, H., 1975, Effect of maternal immunity against development of Marek’s disease and protective ability of vaccine, Natl. Inst. Anim. Health Q. 15:1.Google Scholar
  454. Zander, D.V., 1959, Experiences with epidemic tremor Control, Proc. 8th Annu. Western Poult. Dis. Conf. 18–23.Google Scholar
  455. Zanella, A., Bettoni, V., and Mambelli, N., 1974, Lyophilised turkey herpesvirus (HVT): Stability of vaccine and minimum protective dose, Avian Pathol. 3:15.PubMedGoogle Scholar
  456. Zygraich, N., and Huygelen, C., 1972, Inoculation of one-day-old chicks with different strains of turkey herpesvirus. II. Virus replication in tissues of inoculated animals, Avian Dis. 16:793.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Laurence Noel Payne
    • 1
  1. 1.Houghton Poultry Research StationHoughton, Huntingdon, CambridgeshireEngland

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