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Herpesvirus saimiri and Herpesvirus ateles

  • Bernhard Fleckenstein
  • Ronald C. Desrosiers
Part of the The Viruses book series (VIRS)

Abstract

Herpesvirus saimiri (H. saimiri) is a ubiquitous agent of squirrel monkeys (Saimiri sciureus), a primate species native to the South American rain forests. The virus can easily be isolated from blood and tissue-culture cells of most healthy squirrel monkeys, and there is no evidence so far that H. saimiri is pathogenic in its natural host. After the first report on isolation of H. saimiri from primary kidney-cell cultures by Melendez et al. (1968) from the New England Primate Research Center, the virus was regarded as a harmless indigenous agent of squirrel monkeys. The interest in this virus arose from the observation that H. saimiri is extremely oncogenic in a number of other primate species that are presumably not infected under usual wildlife conditions (Melendez et al., 1969b). Marmoset monkeys of the genus Saguinus consistently develop malignant tumors of the lymphatic system, usually within 2 months of infection. The ability to induce neoplastic disease rapidly and reproducibly has made this system attractive for investigation of the biological, immunological, and molecular parameters of Cell transformation and tumor induction.

Keywords

Malignant Lymphoma Squirrel Monkey Spider Monkey Capuchin Monkey Common Marmoset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Bernhard Fleckenstein
    • 1
  • Ronald C. Desrosiers
    • 2
  1. 1.Institut für Klinische VirologieUniversity of Erlangen-NürnbergErlangenWest Germany
  2. 2.New England Regional Primate Research CenterHarvard Medical SchoolSouthboroughUSA

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