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Immunology of Epstein—Barr Virus

  • Werner Henle
  • Gertrude Henle
Part of the The Viruses book series (VIRS)

Abstract

The Epstein-Barr virus (EBV) was initially detected by electron microscopy in a small percentage of cells cultured from Burkitt lymphomas (BL), the most frequent malignancy of African Children (M.A. Epstein et al., 1964). This tumor had become a special target for virologists because epidemiological observations made in endemic regions pointed to participation of an infectious agent either directly or as a cofactor in its development (cf. Burkitt and Wright, 1970). Despite this background, the virus found in the tumor cells was considered by most virologists to be a harmless passenger because it belonged morphologically to the herpes group of viruses and none of its members had as yet been shown to be potentially oncogenic. The fact that it could not be transmitted to any routine cell cultures, chick embryos, or experimental animals suggested that it was not one of the then known three human herpesviruses (herpes simplex, Cytomegalovirus, and varicella virus) and thus provided the first clue that it was a previously unknown agent (M.A. Epstein et al., 1965).

Keywords

Nasopharyngeal Carcinoma Burkitt Lymphoma Infectious Mononucleosis Early Antigen Antibody Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Werner Henle
    • 1
  • Gertrude Henle
    • 1
  1. 1.The Joseph Stokes, Jr., Research Institute of The Children’s Hospital of PhiladelphiaUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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