The two principal factors which set apart the review of research involving children from studies that use competent adults are the difficulties of obtaining a truly informed consent and the method for assessment of risk/benefit ratio. Since standard procedures for IRB review of research have already been covered in a prior chapter, this chapter will deal solely with those added dimensions regarding the use of minors. Children are defined as persons who have not yet attained the legal age of consent, which is likely to be 18 in most states but can vary widely.
KeywordsHerpes Zoster Minimal Risk Direct Benefit Competent Adult Intellectual Capability
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