Nitroimidazoles as Antiparasitic Agents

  • I. de Carneri
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 42)


The nitroimidazoles were launched on their pharmacological career in 1956 when azomycin or 2-nitroimidazole, a natural product obtained by fermentation, was found active against certain bacteria and Trichomonas, For a decade, nitroimidazole derivatives were used only to combat protozoa of the Trichomonadida order(1)(including Histomonas meleagridis in veterinary medicine), and for Vincent’s angina, a spirochaetal infection. Subsequently their use was extended to other parasitic infections (2), mainly amoebiasis and giardiasis, and only in the last five years have they been definitely employed in bacteriology (3) (Fig. 1) and as radiosensitizers.


Trypanosoma Cruzi Trypanosoma Brucei Cytoplasmic Matrix Antiparasitic Agent Mucocutaneous Leishmaniasis 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • I. de Carneri
    • 1
  1. 1.Department of ParasitologyUniversity of PaviaItaly

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