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Mechanism of Cytotoxicity of Nitroimidazoles

  • D. I. Edwards
  • R. J. Knox
  • D. A. Rowley
  • I. M. Skolimowski
  • R. C. Knight
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 42)

Abstract

The nitroimidazole group of drugs are extensively used for the chemotherapy of anaerobic bacterial and protozoal disease and also for the radiosensitization of hypoxic tumours. In the treatment of hypoxic tumours, of particular clinical value are metronidazole (l-β-hydroxy-ethyl-2-methyl-5-nitroimidazole) and misonidazole (2-nitro-l-imidazolyl-3-methoxy-2-propanol). Both these drugs are important in that they exert a cytotoxic effect in addition to the radiosensitizing effects.

Keywords

Reduction Product Relative Viscosity Hypoxic Tumour Hypoxic Cell Strand Breakage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. I. Edwards
    • 1
  • R. J. Knox
    • 1
  • D. A. Rowley
    • 1
  • I. M. Skolimowski
    • 1
  • R. C. Knight
    • 1
  1. 1.Chemotherapy Research UnitNorth East London PolytechnicLondonEngland

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