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The Pharmacology and Toxicology of 5-Nitroimidazoles

  • G. L. Biagi
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 42)

Abstract

The nitroimidazoles belong to the group of nitroheterocyclic compounds which play an important role as drugs in chemotherapy. The first heterocyclic compound to be used in human medicine was nitrofurazone, a nitrofuran derivative employed during the war for its antibacterial properties for the topical treatment of burns and wounds (1). The discovery of the antibacterial properties of the nitrofurans stimulated interest in nitroheterocyclic compounds as chemotherapeutic agents. As a consequence, several series of nitroheterocyclic compounds were studied. In particular, nitroimidazoles gained importance because of their antiprotozoal activity. The purpose of this paper is to provide a basic introduction to the pharmacology and toxicology of nitroimidazoles as an aid in the study of more detailed aspects which will be covered in the other papers in this Conference on nitroimidazoles.

Keywords

Mutagenic Activity Blood Dyscrasia Amoebic Liver Abscess Antiprotozoal Activity Intestinal Amoebiasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. L. Biagi
    • 1
  1. 1.Istituto di FarmacologiaUniversità di BolognaItaly

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