Lactate Dehydrogenase-Deficient Mutants of Streptococcus Mutans
One approach to the prevention of bacterial infections had its formal beginning over a centruy ago. Pasteur, along with his colleague Joubert, noted that the growth of anthrax bacillus in a urine specimen was inhibited by the presence of other “common” microbes (15). They predicted that the infection of a susceptible host by certain harmless bacteria might prevent subsequent infection by virulent types of bacteria. The acutal mechanism underlying this approach, which has recently been termed replacement therapy, would depend on the ability of the harmless, so-called effector strain to occupy the niche in the susceptible host tissues normally occupied by the pathogen. Once well established there, the effector strain could follow one of several courses to prevent infection by a particular pathogen.
KeywordsEffector Strain Streptococcus Mutans Carious Lesion Blue Coloni Oral Flora
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- 3.Brown, A.T. and C.L. Wittenberger (1972). Fructose-1,6diphosphate-dependent lactate dehydrogenase from a cariogenic streptococcus: purification and regulatory properties. J. Bacteriol. 110: 604–615.Google Scholar
- 6.Gibbons, R.J. and R.J. Fitzgerlad (1969). Dextran induced agglutination of Streptococcus mutans, and its potential role in the formation of microbial dental plaques. J. Bacteriol. 98: 341–346.Google Scholar
- 7.Gibbons, R.J. and J. van Houte (1975). Dental caries. Ann. Rev. Microbiol. 26: 121–136.Google Scholar
- 9.Jenkins, G.N. (1966). In The Physiology of the Mouth. pp 300–305. F.A. Davis Co., Philadelphia, PA.Google Scholar
- 13.Lederberg, J. (1948). Detection of fermentative variants with tetrazolium. J. Bacteriol. 56: 695.Google Scholar
- 15.Pasteur, L. and J.F. Joubert (1877). Charbon et septicemie. Compt. rend. Acad. Sci., Paris 85: 101–115.Google Scholar
- 16.Salanitro, J.P. and P.A. Muirhead (1975). Quantitative methods for the gas chromatographic analysis of short-chain monocarboxylic acids in fermentation media. Appl. Microbiol. 29: 374–381.Google Scholar
- 18.van Houte, J. and D.B. Green (1974). Relationship between the concentration of bacteria in saliva and the colonization of teeth in humans. Infect. Immun. 9: 624–630.Google Scholar
- 20.Wood, N.P. (1966). In Methods in Enzymology, vol IX, pp 718–722. Academic Press, N.Y.Google Scholar