Lactate Dehydrogenase-Deficient Mutants of Streptococcus Mutans

  • Jeffrey D. Hillman
Part of the Basic Life Sciences book series


One approach to the prevention of bacterial infections had its formal beginning over a centruy ago. Pasteur, along with his colleague Joubert, noted that the growth of anthrax bacillus in a urine specimen was inhibited by the presence of other “common” microbes (15). They predicted that the infection of a susceptible host by certain harmless bacteria might prevent subsequent infection by virulent types of bacteria. The acutal mechanism underlying this approach, which has recently been termed replacement therapy, would depend on the ability of the harmless, so-called effector strain to occupy the niche in the susceptible host tissues normally occupied by the pathogen. Once well established there, the effector strain could follow one of several courses to prevent infection by a particular pathogen.


Effector Strain Streptococcus Mutans Carious Lesion Blue Coloni Oral Flora 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jeffrey D. Hillman
    • 1
  1. 1.Forsyth Dental CenterBostonUSA

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