Molecular Cloning in the Streptococci

  • Francis L. Macrina
  • Janet Ash Tobian
  • Kevin R. Jones
  • R. Paul Evans
Part of the Basic Life Sciences book series


The genus Streptococcus contains a large number of species able to cause infection in humans and in animals. Our research efforts have revolved around the study of streptococci that normally reside in the human oral cavity. In this regard, Streptococcus mutans is thought to play an important role in the etiology of dental caries (tooth decay) in humans (5). Its virulence has been well established in animal model systems (see 5) and studies with mutants indicate that S. mutans’ ability to synthesize water-insoluble glucans from sucrose is closely linked to its pathogenicity.


Molecular Cloning Streptococcus Mutans Helper Plasmid Cryptic Plasmid Plasmid Transformation 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Francis L. Macrina
    • 1
  • Janet Ash Tobian
    • 1
  • Kevin R. Jones
    • 1
  • R. Paul Evans
    • 1
  1. 1.Department of MicrobiologyVirginia Commonwealth UniversityRichmondUSA

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