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The Cytoplasmic Control of Protein Synthesis

  • Richard J. Jackson
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 41)

Abstract

After a long period during which to claim to be studying translational control was to invite a variety of negative responses from sympathetic looks to undisguised sneers, it has now become such a respectable topic that no fewer than five reviews published in the last two years (1–5) entirely devoted to it or treat it as a major topic, and a sixth will shortly appear (6). In these circumstances, the last thing in the world that is needed is yet another review which does nothing more than cover the same ground once again. Through a stroke of lucky timing, I do have something new to say on the control of reticulocyte protein synthesis by sugar phosphates and reducing agents, which is discussed in Section VI. In order that those who are unfamiliar with this field should be able to see this control system in its context, I must summarise what is known about other reticulocyte control systems (Sections III–V); I hope that any reader who already feels saturated by this information will forgivingly skip these sections. Finally, I have felt compelled to make some comments on the control of translation in other systems (Sections II and VII), since it seems to me that the reticulocyte system may be attracting too much attention, with the result that regulatory phenomena in other cells are all too often interpreted solely in terms of the reticulocyte model instead of being examined with an open mind. This is not a comprehensive review in the normal sense; I have made no effort to digest the whole mass of literature and to record every contribution. It is my personal interpretation of the state of knowledge (or lack of it) and references are therefore given only to illustrate particular points and to provide the reader with an entry into the literature.

Keywords

Sugar Phosphate Crude Lysate Ternary Complex Formation Cytoplasmic Control Normal Protein Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Richard J. Jackson
    • 1
  1. 1.Department of BiochemistryUniversity of CambridgeCambridgeEngland

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