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Virus-Induced Shut-Off of Host Specific Protein Synthesis

  • Chapter
Protein Biosynthesis in Eukaryotes

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 41))

Abstract

Infection of cells by viruses is often followed by a rapid decline in the synthesis of host cell specific macromolecules, predominantly of protein and RNA (1–3). This phenomenon, called shutoff, was first intensively analyzed in phage infected bacteria. It was shown that adsorption of the phage protein shell (protein ghost) to E. coli leads to a rapid change in membrane permeability followed by cessation of macromolecular synthesis and death of the host cell 5). Even soluble fractions of the phage coat are able to kill E. coli cells (6). Membrane leakiness is rapidly repaired in productively infected E. coli due to phage coded proteins.

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  1. Abt. Molekularbiologie, Physiol. Chem. Inst. Univ. Hamburg, Grindelallee 117, D-2000, Hamburg 13, Germany

    Friedrich Koch, Gebhard Koch & Joachim Kruppa

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  1. Friedrich Koch
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  2. Gebhard Koch
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  1. The Institute for Virology, University of Rome, Rome, Italy

    R. Pérez-Bercoff

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Koch, F., Koch, G., Kruppa, J. (1982). Virus-Induced Shut-Off of Host Specific Protein Synthesis. In: Pérez-Bercoff, R. (eds) Protein Biosynthesis in Eukaryotes. NATO Advanced Study Institutes Series, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4124-6_14

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