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Virus-Induced Shut-Off of Host Specific Protein Synthesis

  • Friedrich Koch
  • Gebhard Koch
  • Joachim Kruppa
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 41)

Abstract

Infection of cells by viruses is often followed by a rapid decline in the synthesis of host cell specific macromolecules, predominantly of protein and RNA (1–3). This phenomenon, called shutoff, was first intensively analyzed in phage infected bacteria. It was shown that adsorption of the phage protein shell (protein ghost) to E. coli leads to a rapid change in membrane permeability followed by cessation of macromolecular synthesis and death of the host cell 5). Even soluble fractions of the phage coat are able to kill E. coli cells (6). Membrane leakiness is rapidly repaired in productively infected E. coli due to phage coded proteins.

Keywords

Protein Synthesis Vesicular Stomatitis Virus Uninfected Cell Total Protein Synthesis Histone mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Friedrich Koch
    • 1
  • Gebhard Koch
    • 1
  • Joachim Kruppa
    • 1
  1. 1.Abt. MolekularbiologiePhysiol. Chem. Inst. Univ. HamburgHamburg 13Germany

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