Mutagenicity of Airborne Particulate Matter in Relation to Traffic and Meteorological Conditions
It is now well established that environmental factors are major causes of cancer in man (Higginson and Muir, 1973). Epidemiological studies have shown that the incidence of lung cancer is higher in urban than in rural areas (Henderson et al., 1975). Urban air contains large amounts of particulate pollutants, which are believed to contribute to this higher lung-cancer incidence (Menck et al., 1974). Furthermore, the carcinogenic potential of organic extracts from airborne particles has been demonstrated in animal experiments (Hueper et al., 1962). These observations have made it increasingly important to identify carcinogenic compounds in ambient air. Since animal studies are expensive and time-consuming, short-term tests for mutagenicity in microbial systems are currently used to identify possible carcinogens.
KeywordsPolycyclic Aromatic Hydrocarbon Mutagenic Activity Polycyclic Aromatic Hydrocarbon Concentration Street Level Airborne Particulate Matter
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- Alfheim, I., M. Moller, S. Larssen, and A. Mikalsen. 1977. Unders+kelse av PAH og mutagene stoffer i Oslo-luft-relasjon til trafikk. Report to Norwegian State Pollution Control Authority. 42 pp.Google Scholar
- Grob, K., and G. Grob. 1969. Splitless injection on capillary columns (Part I and Part II). J. Chromatogr. Sci. 7: 584–591.Google Scholar
- Henderson, B.E., R.J. Gordon, H. Menck, J. Soohoo, S.P. Martin, and M.C. Pike. 1975. Lung cancer and air pollution in Southcentral Los Angeles County. Am. J. Epidemiol. 101: 477–488.Google Scholar
- Higginson, J., and C.S. Muir. 1973. In: Cancer Medicine. J.F. Holland and R. Frei, eds. Lea and Febiger: Philadelphia.Google Scholar
- Hueper, W.C., P. Kotin, E.C. Tabor, W.W. Payne, H. Falk, and E. Sawicki. 1962. Carcinogenic bioassays on air pollutants. Arch. Pathol. 74: 89–116.Google Scholar
- Löfroth, G. 1979. Salmonella/microsome assays of exhaust from diesel and gasoline powered motor vehicles. Presented at International Symposium on Health Effects of Diesel Engine Emissions, Cincinnati, OH.Google Scholar
- Møller, M., and I. Alfheim. 1980. Mutagenicity and PAH analysis of airborne particulate matter. Atmos. Environ. 14: 83–88.Google Scholar
- Talcott, R., and E. Wei. 1977. Brief communication: airborne mutagens bioassayed in Salmonella typhimurium. J. Natl. Cancer Inst. 58: 449–451.Google Scholar
- Van Vaeck, L., and K. Van Cauwenberghe. 1978. Cascade impactor measurements of the size distribution of the major classes of organic pollutants in atmospheric particulate matter. Atmos. Environ. 12: 229–239.Google Scholar