In Vitro and In Vivo Evaluation of Potential Toxicity of Industrial Particles
Alveolar macrophages (AM) protect the lungs by phagocytosis and digestion of inhaled irritant particles and infectious agents. Reduced activity of the AM system can impair the lung’s defensive capacity and increase susceptibility to respiratory disease. Since resistance to infection may be lowered by exposure to an inhalation hazard, changes in the major functional characteristics of AM can be used to monitor environmental stresses in the intact animal. In addition, since these cells can be obtained easily by tracheobronchial lavage and maintained in culture, they are frequently used in in vitro cellular toxicology to assess the potential inhalation hazard of various substances.
KeywordsCopper Smelter Aluminum Smelter Aerosol Exposure Inhalation Hazard Rabbit Alveolar Macrophage
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