Mutagenic Effects of Environmental Particulates in the CHO/HGPRT System
The emission of particulate matter into the atmosphere from stationary fuel combustion and transportation-related sources is a serious environmental problem. Natusch (1978) has shown that trace elements and chemicals associated with particulate matter from coal combustion may constitute a health hazard. In an earlier study, Natusch and Wallace (1974) reported that many known or potential carcinogens are preferentially concentrated on the surface of respirable coal fly ash. According to Davison et al. (1974), greater quantities of trace elements are associated with particles of fly ash too small to be trapped effectively by conventional particulate-control devices. The potential hazard of respirable particles was brought into sharper focus through studies in which organic extracts of fly ash particles (Chrisp et al., 1978; Fisher et al., 1979) and diesel exhaust particulates (Huisingh et al., 1978) were shown to be mutagenic in Salmonella typhimurium.
KeywordsDiesel Engine Chinese Hamster Ovary Cell Mutation Frequency Coal Combustion Diesel Exhaust
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