Abstract
Recent advances in the study of particulate emissions have brought to light several facts concerning their health effects. Many emission sources produce respirable particles with associated organic substances (Waters et al., 1979). These organic substances may be unburned fuel or they may result from pyrosynthetic reactions at or near the combustion source and photosynthetic and oxidative processes that occur after their initial formation (Crittenden and Long, 1976). Some of these organic materials contain known carcinogens and are mutagenic in short-term bioassays (Huisingh et al., 1979). Previous work by Kotin et al. (1966) and by Mittler and Nicholson (1957) gave conflicting results on the mouse skin tumorigenicity of diesel exhaust components. Similar studies with gasoline exhaust revealed a positive tumorigenic response from multiple application of condensates and extracts to mouse skin (Kotin et al., 1964; Mittler and Nicholson, 1957; Hoffmann and Wynder, 1963; Hoffmann et al., 1965). The present study was performed to examine the tumorigenicity of the organics associated with diesel exhaust particulate emissions using a sensitive mouse skin tumorigenesis model (SENCAR) and to compare the tumorigenic potency of the organics from particulate emissions of diesel, gasoline, and related emission sources.
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References
Boutwell, R.K. 1964. Some biological aspects of skin carcinogenesis. Progr. Exp. Tumor Res. 4: 207–250.
Clayson, D.B., and R.C. Garner. 1976. Carcinogenic aromatic amines and related compounds. In: Chemical Carcinogens. C.E. Searle, ed. American Chemical Society: Washington, DC. pp. 366–461.
Crittenden, B.D., and R. Long. 1976. The mechanisms of formation of polynuclear aromatic compounds in combustion systems. In: Polynuclear Aromatic Hydrocarbons. R. Freudenthal and P.W. Jones, eds. Raven Press: New York. pp. 209–223.
Dahl, G.A., J.A. Miller, and E.C. Miller. 1978. Vinyl carbamate as a promutagen and a more carcinogenic analog of ethyl carbamate. Cancer Res. 38: 3793–3804.
Frank, A.L. 1978. Occupational lung cancer. In: Pathogenesis and Therapy of Lung Cancer. C.C. Harris, ed. Marcel Dekker, Inc.: New York. pp. 25–51.
Fujii, M. 1976. Carcinogenic effect of N-butyl-N-nitrosourethane on CDF-1 mice. Gann 67: 231–236.
Gori, G.B., ed. 1977. Toward Less Hazardous Cigarettes: The First Set of Experimental Cigarettes. Department of Health, Education, and Welfare publication no. 76–905. National Institutes of Health: Washington, DC.
Graffi, A., and F. Hoffman. 1966. Strong carcinogenic effect of methl nitrosourea on mouse skin in the drop test. Acta Biol. Med. Ger. 16: K1 - K3.
Hecht, S.S., E. LaVoie, R. Mazzarese, N. Hirota, T. Ohmori, and D. Hoffmann. 1979. Comparative mutagenicity, tumor-initiating activity, carcinogenicity and in vitro metabolism of fluorinated 5-methylchrysenes. J. Natl. Cancer Inst. 63: 855–861.
Hennings, H., and R.R. Boutwell. 1969. Inhibition of DNA synthesis by initiators of mouse skin tumorigenesis. Cancer Res. 29: 510–514.
Hennings, H., B. Michael, and E. Patterson. 1978. Croton oil enhancement of skin tumor initiation by MNNG. Proc. Soc. Exp. Biol. Med. 158: 1–4.
Hoffmann, D., E. Theisz, and E.L. Wynder. 1965. Studies on the carcinogenicity of gasoline exhaust. J. Air Pollut. Contr. Assoc. 15: 162–165.
Hoffmann, D., and E.L. Wynder. 1963. Studies on gasoline engine exhaust. J. Air Pollut. Contr. Assoc. 13: 322–327.
Huisingh, J. Lewtas. (in press). Mutagenic and carcinogenic potency of extracts of diesel and related environmental emissions: preparation and characterization of the samples. Proceedings of the International Symposium of Health Effects of Diesel Engine Emissions.
Huisingh, J., R. Bradow, R. Jungers, L. Claxton, R. Zweidinger, S. Tejada, J. Bumgarner, F. Duffield, M. Waters, V. Simenon, C. Hare, C. Rodriguez, and L. Snow. 1979. Application of bioassay to the characterization of diesel particle emissions. In: Application of Short-term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures. M.D. Waters, S. Nesnow, J.L. Huisingh, S.S. Sandhu, and L. Claxton, eds. Plenum Press: New York. pp. 383–418.
Kotin, P., H.L. Falk, and M. Thomas. 1964. Aromatic hydrocarbons, II. Presence in the particulate phase of gasoline-engine exhausts and the carcinogenicity of exhaust extracts. AMA Arch. Ind. Hyg. Occup. Med. 9: 164–177.
Kotin, P., H.L. Falk, and M. Thomas. 1966. Aromatic hydrocarbons, III. Presence in the particulate phase of diesel-engine exhausts and the carcinogenicity of exhaust extracts. AMA Arch. Ind. Hyg. Occup. Med. 11: 113–120.
Lindenfelser, L.A., E.B. Lillehoj, and H.R. Burmeister. 1974. Aflatoxin and trichothecene toxins: skin tumor induction and synergistic acute toxicity in white mice. J. Natl. Cancer Inst. 52: 113–116.
Mittler, S., and S. Nicholson. 1957. Carcinogenicity of atmospheric pollutants. Ind. Med. Surg. 26: 135–138.
Roe, F.J.C. 1957. Tumor initiation in mouse skin by certain esters of methane sulfonic acid. Cancer Res. 17: 64–67.
Roe, F.J.C., and M.H. Salaman. 1955. Further studies on incomplete carcinogenesis: triethylene melamine (TEM), 1,2-benzanthracene, and ß-propiolactone as initiators of skin tumor formation in the mouse. Br. J. Cancer 9: 177–203.
Salaman, H.H., and F.J.C. Roe. 1953. Incomplete carcinogens: Ethyl carbamate (urethane) as an initiator of skin tumor formation in the mouse. Br. J. Cancer 7: 472–481.
Scribner, J.D. 1973. Tumor initiation by apparently noncarcinogenic polycyclic aromatic hydrocarbons. J. Natl. Cancer Inst. 50: 1717–1719.
Scribner, J.D., and T.J. Slaga. 1975. Tumor intiation by N-acetoxy derivatives of piperidine and N-arylacetamides. J. Natl. Cancer Inst. 54: 491–493.
Searle, C.E. 1966. Tumor initiatory activity of some chloromononitrobenzenes and other compounds. Cancer Res. 26:12–17.
Shamberger, R.J., T.L. Andreone, and C.E. Willis. 1974. Antioxidants and cancer IV. Initiating activity of malonaldehyde as a carcinogen. J. Natl. Cancer Inst. 53: 1771–1773.
Slaga, T.J., G.T. Bowden, B.G. Shapas, and R.K. Boutwell. 1973. Macromolecular synthesis following a single application of alkylating agents used as initiators of mouse skin tumorigenesis. Cancer Res. 33: 769–776.
Slaga, T.J., W.M. Bracken, A. Viaje, D.L. Berry, S.M. Fischer, D.R. Miller, W. Levin, A.H. Conney, H. Yagi, and D.M. Jerina. 1978a. Tumor initiating and promoting activities of various benzo(a)pyrene metabolites in mouse skin. In: Polynuclear Aromatic Hydrocarbons. R.I. Freudenthal and W. Jones, eds. Raven Press: New York. pp. 371–382.
Slags, T.J., S.M. Fischer, L. Triplett, and S. Nesnow. (in press a). Comparison of complete carcinogenesis and tumor initiation in mouse skin: Tumor initiation promotion, a reliable short term assay. In: Proceedings of the Symposium on Short-term In Vivo Carcinogenesis Bioassays.
Slags, T.J., G.L. Gleason, J. DiGiovanni, D.L. Berry, M.R. Juchau, and R.G. Harvey. 1979. Tumor initiating activities of various derivatives of benz(a)anthracene and 7,12-dimethylbenz(a)anthracene in mouse skin. In: Proceedings of the Third International Battelle Conference on Polynuclear Aromatic Hydrocarbons. P.W. Jones and P. Leber, eds. Ann Arbor Press: Ann Arbor, MI. pp. 753–764.
Slags, T.J., A. Sivak, and R.K. Boutwell, eds. 1978b. Carcinogenesis: A Comprehensive Survey, Vol. 2. Mechanisms of Tumor Promotion and Cocarcinogenesis. Raven Press: New York.
Slaga, T.J., L.L. Triplett, and S. Nesnow. (in press b). Mutagenic and carcinogenic potency of extracts of diesel and related environmental emissions: two-stage carcinogenesis in skin tumor sensitive mice (SENCAR). Proceedings of the International Symposium on Health Effects of Diesel Emissions.
Snook, M.E., R.F. Severson, H.C. Higman, R.F. Arrendale, and O.T. Chortyk. 1976. Polynuclear aromatic hydrocarbons of tobacco smoke: Isolation and identification. Zeit. zur Tabak. pp. 250–276.
Swanson, D., C. Morris, P. Hedgecoke, R. Jungers, R. Thompson, and J. Bumgarner. 1978. A rapid analytical procedure for the analysis of benzo(a)pyrene in environmental samples. In: Trends in Fluorescence, Vol. 1, No. 2. Perkin-Elmer Corp.: Norwalk, CT. pp. 22–27.
Van Duuren, B.L. 1976. Tumor-promoting and co-carcinogenic agents in chemical carcinogenesis. In: Chemical Carcinogens. C.E. Searle, ed. American Chemical Society: Washington, DC. pp. 24–51.
Van Duuren, B.L., L. Orvis, and N. Nelson. 1965. Carcinogenicity of epoxides lactones and peroxy compounds, Part II. J. Natl. Cancer Inst. 35: 707–717.
Van Duuren, B.L., A. Sivak, B.M. Goldschmidt, C. Katz, and S. Melchionne. 1969. Carcinogenicity of haloethers. J. Natl. Cancer Inst. 43: 481–486.
Waters, M.D., S. Nesnow, J.L. Huisingh, S.S. Sandu, and L. Claxton, eds. 1978. Application of Short-term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures. Plenum Press: New York.
Wynder, E.L., and D. Hoffmann, eds. 1967. Tobacco and Tobacco Smoke. Academic Press: New York. pp. 133–315.
Zajdela, F., A. Croisy, C. Malaveille, L. Tomatis, and H. Bartsch. 1980. Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride, and bis(chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice. Cancer Res. 40: 352–356.
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Nesnow, S., Triplett, L.L., Slaga, T.J. (1980). Tumorigenesis of Diesel Exhaust, Gasoline Exhaust, and Related Emission Extracts on Sencar Mouse Skin. In: Waters, M.D., Sandhu, S.S., Huisingh, J.L., Claxton, L., Nesnow, S. (eds) Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II. Environmental Science Research, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4121-5_21
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DOI: https://doi.org/10.1007/978-1-4684-4121-5_21
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