Tumorigenesis of Diesel Exhaust, Gasoline Exhaust, and Related Emission Extracts on Sencar Mouse Skin

  • Stephen Nesnow
  • Larry L. Triplett
  • Thomas J. Slaga
Part of the Environmental Science Research book series (ESRH, volume 22)


Recent advances in the study of particulate emissions have brought to light several facts concerning their health effects. Many emission sources produce respirable particles with associated organic substances (Waters et al., 1979). These organic substances may be unburned fuel or they may result from pyrosynthetic reactions at or near the combustion source and photosynthetic and oxidative processes that occur after their initial formation (Crittenden and Long, 1976). Some of these organic materials contain known carcinogens and are mutagenic in short-term bioassays (Huisingh et al., 1979). Previous work by Kotin et al. (1966) and by Mittler and Nicholson (1957) gave conflicting results on the mouse skin tumorigenicity of diesel exhaust components. Similar studies with gasoline exhaust revealed a positive tumorigenic response from multiple application of condensates and extracts to mouse skin (Kotin et al., 1964; Mittler and Nicholson, 1957; Hoffmann and Wynder, 1963; Hoffmann et al., 1965). The present study was performed to examine the tumorigenicity of the organics associated with diesel exhaust particulate emissions using a sensitive mouse skin tumorigenesis model (SENCAR) and to compare the tumorigenic potency of the organics from particulate emissions of diesel, gasoline, and related emission sources.


Mouse Skin Coke Oven Polynuclear Aromatic Hydrocarbon Cigarette Smoke Condensate Linear Dose Response 


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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Stephen Nesnow
    • 1
  • Larry L. Triplett
    • 2
  • Thomas J. Slaga
    • 2
  1. 1.Health Effects Research LaboratoryU.S. Environmental Protection AgencyResearch Triangle ParkUSA
  2. 2.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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