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The Detection of Potential Genetic Hazards in Complex Environmental Mixtures Using Plant Cytogenetics and Microbial Mutagenesis Assays

  • Milton J. Constantin
  • Karen Lowe
  • T. K. Rao
  • Frank W. Larimer
  • James L. Epler
Part of the Environmental Science Research book series (ESRH, volume 22)

Abstract

The recent realization that industrial effluents and wastes could pose health hazards to future generations has led to considerable research on the health effects of these substances and to efforts to regulate their release. The Research Conservation and Recovery Act (RCRA) specifically addresses the potential health and environmental hazards of solid wastes. Evaluation of long-term consequences of exposure to the huge number of potentially hazardous compounds and complex mixtures would tax the scientific community’s whole-animal testing capabilities. Therefore, many short-term bioassays have been developed to rapidly screen compounds for toxicity, mutagenicity, teratogenicity, and carcinogenicity. It is hoped that these short-term tests will predict lealth hazards early in the development of new technologies, allowing technological changes to be made at early stages, and resulting in timely whole-animal testing where screening indicates potential hazards. Time and money should thus be saved in both technological development and biological testing.

Keywords

Chromosome Aberration Chemical Mutagen Strain TA98 Barley Embryo Fine Particle Size Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Milton J. Constantin
    • 1
  • Karen Lowe
    • 1
  • T. K. Rao
    • 2
  • Frank W. Larimer
    • 2
  • James L. Epler
    • 2
  1. 1.Comparative Animal Research LaboratoryUniversity of TennesseeOak RidgeUSA
  2. 2.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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