The Initiating and Promoting Activity of Chemicals Isolated from Drinking Waters in the Sencar Mouse: A Five-City Survey
Means of properly evaluating the carcinogenic risk posed by organics in drinking water are of utmost concern to the U.S. Environmental Protection Agency (EPA). While rodent lifetime exposure and human epidemiological studies serve as the only generally accepted means, the cost and time involved are highly prohibitive. In addition, formulation of human epidemiological data requires human exposure of sufficient magnitude to allow separation of confounding factors from the relationship in question. Since a major part of EPA’s regulatory activities is directed towards preventing significant increases in the carcinogenic risk to the population, quick and reliable investigative methodology is a necessity. Short-term bioassays can be used to identify most potential problems and to provide an initial risk assessment.
KeywordsDrinking Water Phorbol Myristate Acetate Carcinogenic Risk Phorbol Myristate Acetate Human Epidemiological Study
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