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Detection of Organic Mutagens in Water Residues

  • John C. Loper
  • M. Wilson Tabor
Part of the Environmental Science Research book series (ESRH, volume 22)

Abstract

In previous studies (Loper and Lang, 1978; Loper et al., 1978; Lang et al., in press; Kurzepa et al., in press), we used shortterm bioassays to demonstrate the mutagenicity, carcinogenicity, and toxicity of residues prepared from samples of drinking water from six U. S. cities. The samples were processed by Gulf South Research Institute (New Orleans, LA), using reverse osmosis plus XAD resin sorption-desorption as described by Kopfler et al. (1977). Using the Ames test, we found city-specific patterns of dose-dependent mutagenesis that were essentially independent of the microsomal activation system. One or more samples from each city showed reproducible transformation frequencies at least three times the spontaneous frequency. Focus formation induced by these samples was equivalent to malignant transformation as verified in nude mice. In these studies, quantitation of mutagenic and transformation responses were complicated by the toxicity and heterogeneity of the complex residue mixtures.

Keywords

Drinking Water Ames Test Water Chlorination Water Residue Microsomal Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • John C. Loper
    • 1
  • M. Wilson Tabor
    • 1
  1. 1.Departments of Microbiology and Environmental HealthUniversity of Cincinnati College of MedicineCincinnatiUSA

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