Effects of Streptococcal Components on Immunity

  • John H. Schwab
  • Dena L. Toffaletti
  • Roger R. Brown


The group A streptococcus is an example of a bacterial cell from which several, apparently antagonistic, immunomodulating activities have been isolated (5, 6, 7, 8, 9, 10). The substances we have studied are derived from the cell envelope. We have reported that the peptidoglycan isolated from the cell wall contained the adjuvant activity associated with cells and cell walls (7). Many biological properties, which may be relevant to the immunopotentiating activity, have been described for peptidoglycan and the muramyl dipeptide moiety (1). We have been interested in the capacity of peptidoglycan to activate the alternative complement pathway (ACP), since complement can influence the immune system, especially macrophage activity (11). In our studies, peptidoglycan was the most potent activator of the ACP in human serum (5).


Membrane Preparation Crude Cell Extract Adjuvant Activity Muramyl Dipeptide Plaque Form Cell 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • John H. Schwab
    • 1
  • Dena L. Toffaletti
    • 1
  • Roger R. Brown
    • 1
  1. 1.Department of Bacteriology and ImmunologyUniversity of North Carolina Medical SchoolChapel HillUSA

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