Genetic Control of Murine Resistance to SalmonellaTyphimurium Infection

  • Alison D. O’Brien
  • David L. Rosenstreich
  • Irwin Scher


Mice infected with Salmonella typhimurium develop a disease which is similar in its pathogenesis to typhoid fever (42). This facultative intracellular organism multiplies in the phagocytic cells of the murine reticuloendothelial cell system, and unrestricted bacterial growth results in death of the host. However, mice of various inbred strains differ in response to S. typhimurium infection. Some strains of mice invariably succumb to infection with < 10 organisms, whereas other strains survive challenge doses of ≥ 104 bacteria (21, 24). Webster, Schott and Gowen (9, 34, 39–41) were the first to recognize that this differential susceptibility was genetically regulated, and they subsequently developed salmonella-susceptible and resistant mouse strains (39). Although their pioneering work was performed in the 1930’s, the delineation of the genes involved in resistance to murine typhoid occurred only recently.


Inbred Strain Typhoid Fever Recombinant Inbred Backcross Mouse Naval Medical Research Institute 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Alison D. O’Brien
    • 1
  • David L. Rosenstreich
    • 2
  • Irwin Scher
    • 3
    • 4
  1. 1.Department of MicrobiologyUniformed Services University of the Health SciencesBethesdaUSA
  2. 2.The Laboratory of Microbiology and ImmunologyNational Institutes of Dental Research, National Institutes of HealthBethesdaUSA
  3. 3.Department of MedicineUniformed Services University of the Health SciencesBethesdaUSA
  4. 4.The Department of ImmunologyNaval Medical Research InstituteBethesdaUSA

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