The Influence of Bacterial Products on Cyclic Nucleotide Metabolism of Lymphocytes

  • Richard A. Winchurch


A wide variety of bacteria and bacterial products have been shown to influence the immune system. This arsenal of bacterial immunomodulating agents is of diverse origin and includes mycobacteria and their products, Corynebacterium parvum, Bordetella pertussis, gram negative lipopolysaccharides (LPS), the enterotoxins from Vibrio cholera and streptococcal products. Specific effects elicited by many of these substances will be discussed in detail elsewhere in this volume. The present discussion will be confined to two of these materials, LPS and Vibrio cholera enterotoxin and will be directed toward possible mechanisms by which these substances are able to mediate both positive and negative effects on the immune system.


Cholera Toxin Bordetella Pertussis Mixed Lymphocyte Culture Normal Immune Response Suppressor Cell Activity 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Richard A. Winchurch
    • 1
  1. 1.Department of Surgery, Baltimore Firefighters Research LaboratoryJohns Hopkins University School of Medicine at Baltimore City HospitalsBaltimoreUSA

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