Bi-Directional Macrophage-Lymphocyte Interactions Modulate Immune Responses

  • J. J. Oppenheim
  • P. S. Steeg
  • R. N. Moore


The activation of macrophages and lymphocytes is initiated by exogenous stimuli which often are bacterial in origin. Some of the most potent activating agents are bacterial endotoxin lipopoly- saccharide (LPS), antigenic bacterial components and exotoxins. Macrophages and lymphocytes in turn modulate each other’s level of activation through cell contact and/or mediator dependent mechanisms. For example, some macrophage products suppress lymphocyte proliferation and antibody production. These include thymidine, arginase, prostaglandins and oxygen metabolites, as will be discussed by Dr. Hoffeld (8). Conversely, interferon produced by lymphocytes may have suppressive effects on the activity of macrophages (9). In addition, macrophages and lymphocytes stimulate each other in many ways. In this presentation, we will discuss the multiplicity of endogenous pathways by which lymphocytes and macrophages mutually augment each other’s reactions in their effort to eliminate bacteria or other non-self antigens.


Migration Inhibitory Factory Peritoneal Exudate Cell Human Peripheral Blood Monocyte Multiple Biological Effect Cytophilic Antibody 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. J. Oppenheim
    • 1
  • P. S. Steeg
    • 1
  • R. N. Moore
    • 1
  1. 1.NIH, NIDRBethesdaUSA

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