Pertussis Induced Immunomodulation

  • Thomas Klein
  • William Benjamin
  • Alvin Winters
  • Herman Friedman


Bordetellapertussis (pertussis) is a gram negative coccobacillus and was identified to be the etiological agent of “whooping cough” by Bordet and Gengou in 1906 (7). Much of the early work on pertussis was concerned with identifying the protective antigens so that an effective vaccine could be produced for humans. A whole cell vaccine was introduced in the 1940’s and today is administered world-wide to millions of infants (31). The present vaccine appears to be of major benefit in preventing infant whooping cough, but because of its associated toxicity recent emphasis has been placed on developing a non-whole cell, more highly purified vaccine (40).


Peritoneal Macrophage Acid Phosphatase Activity Pertussis Vaccine Macrophage Function Peritoneal Cell 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Thomas Klein
    • 1
  • William Benjamin
    • 1
  • Alvin Winters
    • 1
  • Herman Friedman
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

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