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Pertussis Induced Immunomodulation

  • Thomas Klein
  • William Benjamin
  • Alvin Winters
  • Herman Friedman

Abstract

Bordetellapertussis (pertussis) is a gram negative coccobacillus and was identified to be the etiological agent of “whooping cough” by Bordet and Gengou in 1906 (7). Much of the early work on pertussis was concerned with identifying the protective antigens so that an effective vaccine could be produced for humans. A whole cell vaccine was introduced in the 1940’s and today is administered world-wide to millions of infants (31). The present vaccine appears to be of major benefit in preventing infant whooping cough, but because of its associated toxicity recent emphasis has been placed on developing a non-whole cell, more highly purified vaccine (40).

Keywords

Peritoneal Macrophage Acid Phosphatase Activity Pertussis Vaccine Macrophage Function Peritoneal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Thomas Klein
    • 1
  • William Benjamin
    • 1
  • Alvin Winters
    • 1
  • Herman Friedman
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

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