The Effects of Endotoxin on Macrophages and T-Lymphocytes

  • David L. Rosenstreich
  • Stefanie N. Vogel


The immune response is generated by a complex series of interactions between three major lymphoreticular cell types, macrophages and B and T lymphocytes (Fig. 1). This response is initiated by the interaction of an external stimulus, such as an antigen or mitogen, with each of all of these cells. The initial stimulation also results in the production of a number of soluble intercellular messengers i.e., lymphokines or monokines, that act within the system to produce a marked amplification of the response.


Migration Inhibitory Factor Kill Tumor Cell Bacterial Lipopolysaccharide Macrophage Secretion Lymphocyte Activate Factor 
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  1. 1.
    Allison, A. C., and Davies, A. J. S., 1971, Requirement of thymus t-dependent lymphocytes for potentiation by adjuvants and antibody formation. Nature. 233: 330.PubMedCrossRefGoogle Scholar
  2. 2.
    Chedid, L., Parant, M., Damais, C., Parant, F., Juy, D., and Galelli, A., 1976, Failure of endotoxin to increase nonspecific resistance to infection of lipopolysaccharide low-responder mice. Infection and Immunity 13: 722.PubMedGoogle Scholar
  3. 3.
    Doe, W., and Henson, P. M., 1979, Macrophage stimulation by bacterial lipopolysaccharides III. Selective unresponsiveness of C3H/HeJ macrophages to the lipid A differentiation signal. J. Immunol. 123: 2304.PubMedGoogle Scholar
  4. 4.
    Farrar, J. J., Mizel, S. B., Fuller-Bonar, J., Hilfiker, M. L., and Farrar, W. L., 1980, Lps-mediated adjuvanticity, effect of Lps on the production of T-cell growth factor (IL-2). In Microbiology. 1980. American Society of Microbiology, Washington, D. C. (in press).Google Scholar
  5. 5.
    Glode, L., Jacques, A., Mergenhagen, S. E., and Rosenstreich, D. L., 1977, Resistance of macrophages from C3H/HeJ mice to the in vitro cytotoxic effects of endotoxin,. J. Immunol. 119: 162.PubMedGoogle Scholar
  6. 6.
    Code, L., and Rosenstreich, D. L., 1976, Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles. J. Immunol. 117: 2061.Google Scholar
  7. 7.
    Green, S., Carswell, -E., Old, L. J., Fiore, N., Dobriansky, A., Mamaril, F., and Schwartz, M. K., 1974, Mechanisms of endotoxin- induced tumor hemorrhagic necrosis. Proc. Am. Assoc. Cancer Res., 15: 139.Google Scholar
  8. 8.
    Koenig, S., Hoffman, M. K., and Thomas, L., 1977, Induction of phenotypic lymphocyte differentiation in Lps unresponsive mice by an Lps-induced serum factor and by lipid A-associated protein. J. Immunol. 118: 1910.PubMedGoogle Scholar
  9. 9.
    McGhee, J. R., Farrar, J. J., Michalek, S. M., Mergenhagen, S. E., and Rosenstreich, D. L., 1979, Cellular requirements for lipopolysaccharide adjuvanticity: A role for both T lymphocytes and macrophages in in vitro responses to particulate antigens. J. Exp. Med. 149: 793.Google Scholar
  10. 10.
    Moeller, G. R., Terry, L., and Snyderman, R., 1978, The inflammatory response and resistance to endotoxin in mice. J. Immunol. 120: 116.PubMedGoogle Scholar
  11. 11.
    Moore, R. N., Oppenheim, J. J., Farrar, J. J., Carter, C. S., and Shadduck, R. K., 1980, Macrophage activation by CSF: stimulation of LAF (IL-1) production. In Microbiology 1980. Ed. D. S. Schlesinger, American Society of Microbiology, Washington, D. C. (in press).Google Scholar
  12. 12.
    O’Brien, A. D., Rosenstreich, D. L., Scher, I., Campbell, G. H., MacDermott, R. P., and Formal, S. B., 1980, Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the Lps gene. J. Immunol. 124: 20PubMedGoogle Scholar
  13. 13.
    O’Briend, A. D., Scher, I., and Formal, S. B., 1979, Effects of silica on the innate resistance of inbred mice to Salmonella typhimurium infection. Infection and Immunity 25: 513.Google Scholar
  14. 14.
    Peavy, D. L., Baugn, R. E., and Musher, D. L., 1978, Strain dependent cytotoxic effects of endotoxin for mouse peritoneal macrophages. Infection and Immunity, 21: 310.PubMedGoogle Scholar
  15. 15.
    Rosenstreich, D. L., The macrophage. In Cell Biology of Immunity and Information. Eds. J. Oppenheim, M. Potter and D. L. Rosenstreich, Elsevier-North Holland, New York (in press).Google Scholar
  16. 16.
    Rosenstreich, D. L., Gode, L. M., Wahl, L. M., Sandberg, A. L., and Mergenhagen, S. E., 1977, Analysis of the cellular defects of the endotoxin unresponsive C3H/HeJ mouse. In Microbiology 1977. Ed. D. S. Schlesinger, American Society of Microbiology, Washington, D. C., pp. 314.Google Scholar
  17. 17.
    Rosenstreich, D. L., Groves, M., O’Brien, A., and Taylor, B. A., 1979, Genetic control of natural resistance to infection in mice. In The molecular Basis of the Infective Process. Eds. H. Smith, J. J. Skehel and M. J. Turner, Berlin: Dahlem Konferenzen, Verlag Chemie GmbH. (in press).Google Scholar
  18. 18.
    Rosenstreich, D. L., Vogel, S. N., Jacques, A. R., Wahl, L. M., and J. J. Oppenheim, 1978, Macrophage sensitivity to endotoxin. Genetic control by a single codominant gene. J. Immunol. 121: 1664.Google Scholar
  19. 19.
    Ruco, L., and Meltzer, M. S., 1978, Defective tumoricidal capacity of macrophages from C3H/HeJ mice. J. Immunol. 120: 329.PubMedGoogle Scholar
  20. 20.
    Ruco, L. P., Meltzer, M. S., and Rosenstreich, D. L., 1978, Macrophage activation for tumor cytotoxicity: Control of macrophage tumoricidal capacity by the LPS gene. J. Immunol. 121: 543.Google Scholar
  21. 21.
    Ryan, J. L., Glode, L.M., and Rosenstreich, D. L., 1979, Lack of responsiveness of C3H/HeJ macrophages to lipopolysaccharide: The cellular basis of LPS stimulated metabolism. J. Immunol. 122: 932.PubMedGoogle Scholar
  22. 22.
    Tagliabue, A., McCoy, J. L., and Herberman, R., 1978, Refrac-toriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J. Immunol. 121: 1223.PubMedGoogle Scholar
  23. 23.
    Vogel, S. N., Marshall, S. T., and Rosenstreich, D. L., 1979, Analysis of the effects of lipopolysaccharide on macrophages: Differential phagocytic responses of C3H/HeN and C3H/HeJ macro-phages iji vitro. Infection and Immunity. 25: 328.PubMedGoogle Scholar
  24. 24.
    Vogel, S. N., and Rosenstreich, D. L., 1979, Defective Fc receptor-mediated phagocytosis in C3H/HeJ macrophages I. Correction by lymphokine-induced stimulation. J. Immunol. 123: 2842.Google Scholar
  25. 25.
    Vogel, S. N., Moore, R. N., Sipe, J. D., and Rosenstreich, D. L., 1980, BCG-induced enhancement of endotoxin sensitivity in C3H/HeJ mice. I. In vivo studies. J. Immunol. (in press).Google Scholar
  26. 26.
    Mergenhagen, S. E., 1979, Defective prostaglandon synthesis by C3H/HeJ mouse macrophages stimulated with endotoxin preparations. Infection and Immunity. 23: 8.PubMedGoogle Scholar
  27. 27.
    Watson, J., Largen, M., and McAdam, K. P. W. J., 1978, Genetic control of endotoxic responses in mice. J. Exp. Med. 147: 39.PubMedCrossRefGoogle Scholar
  28. 28.
    Weinberg, J. B., Chapman, H. A., and Hibbs, J. B., 1978, Characterization of the effects of endotoxin on macrophage tumor killing. J. Immunol. 121: 72.PubMedGoogle Scholar
  29. 29.
    Weiner, E., and Levanon, D., 1968, The in vitro interaction be-tween bacterial lipopolysaccharide and differentiating monocytes. Lab. Invest. 19: 584.Google Scholar
  30. 30.
    Wilton, J. M. A., Rosenstreich, D. L., and Oppenheim, J. J., 1975, Requirement of bone-marrow derived lymphocytes for macrophage activation by bacterial lipopolysaccharide. J. Immunol. 114: 388.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • David L. Rosenstreich
    • 1
    • 2
    • 3
  • Stefanie N. Vogel
    • 1
    • 2
    • 3
  1. 1.Department of MedicineAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of MicrobiologyAlbert Einstein College of MedicineBronxUSA
  3. 3.Laboratory of Microbiology and ImmunologyNational Institute of Dental Research National Institutes of HealthBethesdaUSA

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