Ribosomal Vaccines as Immunomodulators
“Ribosomal vaccines” can be defined as ribosome-rich subcellular extracts of microorganisms used as vaccines. Extracts of this sort have been shown to be highly protective against a number of experimental bacterial and fungal infections, but their mechanisms of protection are still under investigation (1). This paper is concerned with protection induced by such subcellular extracts prepared from Salmonella typhimurium. Experiments have been carried out using a murine model of salmonellosis in which animals were immunized intraperitoneally and challenged three weeks later, intraperitoneally. Survival of vaccinated and control animals was followed for 30 to 40 days post-challenge.
KeywordsOuter Membrane Protein Protective Antigen Challenge Dose Protective Capacity Prolong Survival Time
Unable to display preview. Download preview PDF.
- 13.Rudbach, J. A., and Reed, N. D., 1977, Immunological responses of mice to lipopolysaccharide: Lack of secondary responsiveness by C3H/HeJ mice. Infect. Immun. 16: 513.Google Scholar
- 14.Eisenstein, T. K., and Angerman, C. R., 1978, Immunity to experimental Salmonella infection: Studies on the protective capacity and immunogenicity of lipopolysaccharide, acetone-killed cells, and ribosome-rich extracts of Salmonella typhimurium in C3H/HeJ and CD-I mice. J. Immunol. 121: 1010.PubMedGoogle Scholar
- 15.Fisher, R. A., and Yates, F., 1963, Statistical tables for bio-logical, agricultural and medical research, p. 68. 6th ed. Hafner Publishing Co., New York.Google Scholar
- 16.Nowotny, A., 1969, Basic exercises in immunochemistry, p. 144. A laboratory manual. Springer-Verlag, NY.Google Scholar