Ribosomal Vaccines as Immunomodulators

  • T. K. Eisenstein
  • C. R. Angerman
  • L. W. Deakins


“Ribosomal vaccines” can be defined as ribosome-rich subcellular extracts of microorganisms used as vaccines. Extracts of this sort have been shown to be highly protective against a number of experimental bacterial and fungal infections, but their mechanisms of protection are still under investigation (1). This paper is concerned with protection induced by such subcellular extracts prepared from Salmonella typhimurium. Experiments have been carried out using a murine model of salmonellosis in which animals were immunized intraperitoneally and challenged three weeks later, intraperitoneally. Survival of vaccinated and control animals was followed for 30 to 40 days post-challenge.


Outer Membrane Protein Protective Antigen Challenge Dose Protective Capacity Prolong Survival Time 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • T. K. Eisenstein
    • 1
  • C. R. Angerman
    • 1
  • L. W. Deakins
    • 1
  1. 1.Department of Microbiology and ImmunologyTemple University School of MedicinePhiladelphiaUSA

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