The Lipid Bilayer, Mechanisms of Fusion and Transmembrane Transport
DR. CULLIS: Fusion is among the most important events that takes place in the cytoplasm including, for example, the blebbing off of various secretory granules to fuse with the membrane surface, the fusion processes involved in interorganelle transport, the virus blebbing off process, on endocytotic processes, such as occur for coated vesicles, which then fuse to form secondary lysosomes. In addition to fusion events, there are situations where you appear to have continuity between two organelles (Morre et al., 1978). This may be between rough endoplasmic reticulum and the outer mitochondrial membrane or between the golgi and the smooth endoplasmic reticulum as well as various secretory vesicles. These observations are of interest from the point of view of lipids that have very different properties from what we normally think they should have in a membrane. In particular, we are concerned with the roles of lipids which prefer non-bilayer arrangements in isolation.
KeywordsLipid Bilayer Rough Endoplasmic Reticulum Myoblast Fusion Chromaffin Granule Sorting Sequence
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