Quantification of Red Blood Cell Morphology

  • James W. Bacus


The description of red blood cells extends back to the earliest days of the development of the microscope. In 1658 Swammerdam described the oval red blood cells of the frog, and in 1673 Leeuwenhoek discovered the red cells in human blood and described them as circular in contrast to amphibian cells. In 1770 Hewson published detailed descriptions of structure, form, and dimensions of red blood cells from different animals, including man. In 1846 Gulliver published measurements of red cell size (diameter) on 485 species of vertebrates.


Iron Deficiency Cell Area Hemoglobin Content Bivariate Distribution Megaloblastic Anemia 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • James W. Bacus
    • 1
  1. 1.Medical Automation Research UnitRush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

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