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Vitamin D and the Intestinal Absorption of Calcium and Phosphate

  • Robert H. Wasserman

Abstract

The transport of calcium and phosphate (P i) across the intestinal epithelium has been studied extensively in recent years and a considerable number of these investigations have been concerned with the action of vitamin D. It has been known for several decades that vitamin D is required for the optimal absorption of calcium (Nicolaysen et al., 1953) and, more recently, that there is also a direct effect of vitamin D on phosphate transport (Harrison and Harrison, 1961, 1963; Kowarski and Schachter, 1969). For many years, it was held that phosphate transport occurred secondarily to calcium transport, but this notion has been essentially discarded. Vitamin D has proven to be a useful variable in the study of these processes for a comparison can be made between the efficiency of calcium and phosphate transport in the presence and absence of vitamin D and, importantly, this allows an assessment of the molecular changes that coincide with vitamin D action (reviewed in Wasserman, 1980). Some of the recorded vitamin D-related macromolecular changes most probably bear on the stimulation of transport reactions and offer a means of gaining insight into the molecular basis of calcium and phosphate transport.

Keywords

Brush Border Brush Border Membrane Calcium Metabolism Phosphate Transport Intestinal Brush Border Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert H. Wasserman
    • 1
  1. 1.Department of Physiology, New York State College of Veterinary MedicineCornell UniversityIthacaUSA

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