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Ion-Transporting ATPases

Characterizing Structure and Function with Paramagnetic Probes
  • Charles M. Grisham

Abstract

ATP-hydrolyzing enzymes, which couple the free energy of hydrolysis of ATP to the transport of monovalent or divalent cations, are ubiquitous constituents of biological membranes. In our laboratory, we have been involved in a characterization of three of these transport systems, including the Na+/K+-ATPase and Mg2+-ATPase from kidney plasma membrane and the Ca2+-ATPase from sarcoplasmic reticulum. A specific transport function has not yet been assigned to the Mg2+-ATPase, but the other two enzymes have become model systems for the study of structure-function relationships and energy coupling in membranes.

Keywords

Sarcoplasmic Reticulum Divalent Metal Coordination Geometry Water Proton Active Site Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Charles M. Grisham
    • 1
  1. 1.Department of ChemistryUniversity of VirginiaCharlottesvilleUSA

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