Rules and the Economics of Energy Balance in Coupled Vectorial Processes

  • William P. Jencks


We would like to understand what a coupled vectorial process (CVP) is and how it works. Progress toward this goal demands that the right questions be asked and answers to them found; we should know what questions need to be answered in order that we can say that we understand how a CVP works. It is frequently suggested that coupling in active transport and other CVPs results from changing affinities for ligands (e.g., Ca2+, Na+, H+), “energized states,” and particular steps with “energy coupling” (e.g., a “power stroke”). Such concepts may be useful if they are clearly defined, but can slow progress if they give a sense that a mechanism is understood when it is not.


Ternary Complex Myosin Head Noncovalent Complex Power Stroke Forward Rate Constant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Gerstein, J., and Jencks, W. P. (1964). J. Am. Chem. Soc. 86, 4655–4663.CrossRefGoogle Scholar
  2. Hasselbach, W. (1974). In The Enzymes (P. D. Boyer, ed.), 3rd ed., Vol. 10, pp. 431–467, Academic Press, New York.Google Scholar
  3. Highsmith, S. (1976). J. Biol. Chem. 251, 6170–6172.Google Scholar
  4. Hill, T. L. (1977). Free Energy Transduction in Biology, Academic Press, New York.Google Scholar
  5. Hopfield, J. J. (1974). Proc. Natl. Acad. Sci. USA 71, 4135–4139.CrossRefGoogle Scholar
  6. Jencks, W. P. (1975). Adv. Enzymol. 43, 219–410. Jencks, W. P. (1980a). Adv. Enzymol. 51, 75–106.Google Scholar
  7. Jencks, W. P. (1980b). In Molecular Biology, Biochemistry and Biophysics (F. Chapeville and A.-L. Haenni, eds.), Vol. 32, pp. 3–25, Springer-Verlag, Berlin.Google Scholar
  8. Jencks, W. P. (1981). Proc. Natl. Acad. Sci. USA 78, 4046–4050.CrossRefGoogle Scholar
  9. Paúflng, L. C. (1948). Am. Sci. 36, 51–88.Google Scholar
  10. Punzengruber, C., Prager, R., Kolassa, N., Winkler, F., and Suko, J. (1978). Eur. J. Biochem. 92, 349–359. Taylor, E. W. (1979). Crit. Rev. Biochem. 6, 103–164.Google Scholar
  11. Weber, G. (1975). Adv. Protein Chem. 29, 1–83.CrossRefGoogle Scholar
  12. Wyman, J., Jr. (1964). Adv. Protein Chem. 19, 223–286.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • William P. Jencks
    • 1
  1. 1.Graduate Department of BiochemistryBrandeis UniversityWalthamUSA

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