Rules and the Economics of Energy Balance in Coupled Vectorial Processes
We would like to understand what a coupled vectorial process (CVP) is and how it works. Progress toward this goal demands that the right questions be asked and answers to them found; we should know what questions need to be answered in order that we can say that we understand how a CVP works. It is frequently suggested that coupling in active transport and other CVPs results from changing affinities for ligands (e.g., Ca2+, Na+, H+), “energized states,” and particular steps with “energy coupling” (e.g., a “power stroke”). Such concepts may be useful if they are clearly defined, but can slow progress if they give a sense that a mechanism is understood when it is not.
KeywordsTernary Complex Myosin Head Noncovalent Complex Power Stroke Forward Rate Constant
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- Hasselbach, W. (1974). In The Enzymes (P. D. Boyer, ed.), 3rd ed., Vol. 10, pp. 431–467, Academic Press, New York.Google Scholar
- Highsmith, S. (1976). J. Biol. Chem. 251, 6170–6172.Google Scholar
- Hill, T. L. (1977). Free Energy Transduction in Biology, Academic Press, New York.Google Scholar
- Jencks, W. P. (1975). Adv. Enzymol. 43, 219–410. Jencks, W. P. (1980a). Adv. Enzymol. 51, 75–106.Google Scholar
- Jencks, W. P. (1980b). In Molecular Biology, Biochemistry and Biophysics (F. Chapeville and A.-L. Haenni, eds.), Vol. 32, pp. 3–25, Springer-Verlag, Berlin.Google Scholar
- Paúflng, L. C. (1948). Am. Sci. 36, 51–88.Google Scholar
- Punzengruber, C., Prager, R., Kolassa, N., Winkler, F., and Suko, J. (1978). Eur. J. Biochem. 92, 349–359. Taylor, E. W. (1979). Crit. Rev. Biochem. 6, 103–164.Google Scholar