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Functional and Topological Aspects of the Mitochondrial Adenine Nucleotide Carrier

  • P. V. Vignais
  • M. R. Block
  • F. Boulay
  • G. Brandolin
  • G. J. M. Lauquin

Abstract

The vectorial exchange between the mitochondrial and the cytosolic pools of ADP and ATP is catalyzed by a specific carrier protein located in the inner mitochondrial membrane (Klingenberg, 1976; Vignais, 1976). This function appears to be a general attribute of eukaryotic cells. Even in respiration-deficient mutants of the yeast Saccharomyces cerevisiae that are incapable of oxidative phosphorylation, the ADP/ATP carrier is still functional, and its molecular properties appear to be preserved intact (Kolarov et al., 1972; Subík et al., 1974). After a brief survey of the literature on the functioning of ADP/ATP transport in the cell, we shall focus on recent physical and chemical approaches to investigate the topography of the ADP/ATP carrier in an attempt to better comprehend its mechanism.

Keywords

Mitochondrial Membrane Carrier Protein Adenine Nucleotide Cyanogen Bromide Substrate Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • P. V. Vignais
    • 1
    • 2
  • M. R. Block
    • 1
    • 2
  • F. Boulay
    • 1
    • 2
  • G. Brandolin
    • 1
    • 2
  • G. J. M. Lauquin
    • 1
    • 2
  1. 1.Laboratoire de Biochimie (INSERM U. 191 et CNRS/ERA 903), Département de Recherche FondamentaleCentre d'Etudes NucléairesGrenoble CedexFrance
  2. 2.Faculté de MédecineGrenobleFrance

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