Compositional Domain Structure of Lipid Membranes
During the past few years it has become evident that the molecular constituents of biological membranes are not randomly organized within the bilayer matrix and that many of their physical and functional properties are sensitive to the particular way in which lipid and protein molecules are distributed within the bilayer (Taylor et al., 1971; Shimshick and McConnell, 1973; Hui and Parsons, 1975; Fishman and Brady, 1976; Papahadjopoulos et al., 1976; van Dijck et al.,1978; Thompson, 1978; Correa-Freire et al., 1979). There are various types of ordered molecular arrangements, ranging from nonspecific aggregation or lateral phase separation processes to highly specific molecular interactions leading to the formation of complex structural patterns (Satir, 1976; Lee, 1977; Caspar et al., 1977; Makowski et al., 1977; Wallace and Engelman, 1978). In general, the lateral distribution of molecules in a lipid bilayer is dictated by the energetics of the interactions between the various components and as such is susceptible of being altered by changes in temperature, pH, ionic strength, concentration of ligand molecules, or other physicochemical variables (Wallace and Engelman, 1978; Pearson et al.,1979). The compositional domain structure of lipid membranes has been investigated by direct visualization using electron microscopy (Caspar et al.,1977; Pearson et al., 1979; Hui, 1981) or by appropriately transforming spectroscopic and physicochemical data into the parameters describing the lateral organization of the membrane (von Dreele, 1978; Wolber and Hudson, 1979; Klausner et al.,1980; Kleinfeld and Solomon, 1982). Recently we have developed a system of Monte Carlo calculations (see Binder, 1979, for a review on Monte Carlo methods) that allows us to generate with the computer lipid and protein distributions and to relate these distributions with various physical and functional properties of the mambrane (Freire and Snyder, 1980a,b, 1982; Snyder and Freire, 1980).
KeywordsLateral Distribution Monte Carlo Calculation Percolation Process Lateral Organization Physicochemical Variable
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