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Biosynthesis of Mitochondrial Membrane Proteins

  • Robert O. Poyton
  • Gary Bellus
  • Ann-Louise Kerner

Abstract

Current interest in membrane biogenesis is focused on a series of questions that pertain to: the structure and regulation of genes for membrane proteins; the routes taken by membrane proteins and lipids from their sites of synthesis in the cell to their sites of insertion in the membrane; the coordination between the synthesis of membrane proteins and lipids; and the mechanisms by which proteins and lipids are inserted into the membrane bilayer so as to ensure its continued asymmetry. In considering the biogenesis of mitochondrial membranes, these questions must be extended to include, in addition, the respective roles played by mitochondrial and nuclear genomes in the assembly process. In this review we will first briefly summarize the coordination between nuclear and mitochondrial genomes in mitochondrial biogenesis and then discuss the pathways followed by nuclear and mitochondrial gene products into the genetic mosaic of the inner mitochondrial membrane.

Keywords

Mitochondrial Membrane Mitochondrial Genome INTERMEMBRANE Space Leader Peptide ATPase Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert O. Poyton
    • 1
  • Gary Bellus
    • 1
  • Ann-Louise Kerner
    • 2
  1. 1.Department of Molecular, Cellular, and Developmental BiologyUniversity of ColoradoBoulderUSA
  2. 2.Department of BiochemistryUniversity of Connecticut Health CenterFarmingtonUSA

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