Photoactivated Hydrophobic Reagents for Integral Membrane Proteins

A Critical Discussion
  • Hagan Bayley


Photoactivated hydrophobic reagents are being developed to label those regions of integral membrane proteins that lie within the hydrocarbon core of the lipid bilayer. There are three goals. First, we wish to have a collection of reagents that react entirely from within the bilayer and to a negligible extent from the aqueous phase. Second, we would like to label, without discrimination, all the functional groups exposed to the hydrocarbon core of the membrane. A third goal is to make reagents that will label integral proteins at points that are at defined distances from the surface of the membrane.


Lipid Bilayer Newcastle Disease Virus Cholera Toxin Integral Membrane Protein Fatty Acyl Chain 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Hagan Bayley
    • 1
  1. 1.Department of Biochemistry, College of Physicians & SurgeonsColumbia UniversityNew YorkUSA

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