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Experiment, Hypothesis, and Theory in the Development of Concepts of Cell Membrane Structure 1930–1970

  • J. F. Danielli

Abstract

Many of the basic hypotheses concerning membrane structure were developed in the period 1900–1945. From 1945 to the present, intensive experimental study of these hypotheses has left our concepts of the role of lipids in the membrane largely unchanged. It has also greatly extended the evidence for a variety of roles for proteins in the membrane. Information about the way in which proteins enter into membrane structure, and how they carry out their roles, has been remarkably extended since 1960. In this review, I shall analyze the development of the basic hypotheses in terms of the interplay between hypothesis, experiment, and theory, as it occurred during the period 1930–1970.

Keywords

Free Energy Lipid Bilayer Surface Free Energy Prime Mover Bilayer Structure 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. F. Danielli
    • 1
  1. 1.Danielli Associates and Life Sciences DepartmentWorcester Polytechnic InstituteWorcesterUSA

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