Experiment, Hypothesis, and Theory in the Development of Concepts of Cell Membrane Structure 1930–1970
Many of the basic hypotheses concerning membrane structure were developed in the period 1900–1945. From 1945 to the present, intensive experimental study of these hypotheses has left our concepts of the role of lipids in the membrane largely unchanged. It has also greatly extended the evidence for a variety of roles for proteins in the membrane. Information about the way in which proteins enter into membrane structure, and how they carry out their roles, has been remarkably extended since 1960. In this review, I shall analyze the development of the basic hypotheses in terms of the interplay between hypothesis, experiment, and theory, as it occurred during the period 1930–1970.
KeywordsFree Energy Lipid Bilayer Surface Free Energy Prime Mover Bilayer Structure
Unable to display preview. Download preview PDF.
- Danielli, J. F. (1939a). Proc. R. Soc. London Ser. B 127, 34–35.Google Scholar
- Danielli, J. F. (1939b). Proc. R. Soc. London Ser. B 127, 73.Google Scholar
- Dayson, H., and Danielli, J. F. (eds.) (1943). In The Permeability of Natural Membranes, Cambridge University Press, London.Google Scholar
- Gorter, E., and Grendal, F. (1926). Proc. K. Acad. Wetensoh. Amsterdam 29, 314.Google Scholar
- Hober, R. (1945). Physical Chemistry of Cells and Tissues, Churchill, London.Google Scholar