Specificity of Cell-Mediated Immunoreactivity in Melanoma and Comments on the Nature of Serum Blocking Factors
Malignant melanoma is, from the immunological viewpoint, one of the most extensively studied of all cancers. It is sometimes stated that the reason lies in the tendency of melanoma to undergo spontaneous regression. The assumption is made that regression necessarily has an immunological basis and furthermore that host immunity should thus be more readily demonstrable in melanoma than in other cancers. These concepts are simplistic: tumor regression might have many different mechanisms, and identifiable criteria of immunoreactivity in melanoma patients are typical of many cancers. Nevertheless, there are good practical reasons for choosing to study melanoma as a model of tumor immunity. In Queensland, melanoma is not uncommon; the incidence is the highest in the world at over 30 per 100,000, and clinical material is thus relatively abundant. The visibility of the cutaneous tumor, and intensive health education, combine to ensure that many melanomas are detected at an early stage, identified by experienced clinicians and histopathologists, and removed successfully by adequate surgery (Smith, 1979).
KeywordsMelanoma Patient Soluble Antigen Tumor Extract Melanoma Antigen Adherence Inhibition
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