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Clinical Significance of Tumor-Associated Antigens and Antitumor Antibodies in Human Malignant Melanoma

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Book cover Melanoma Antigens and Antibodies

Abstract

The concept that an immune response similar to that of infectious diseases is elicited in patients suffering from malignancy is well established. This concept was first developed during the early 1900s when it was observed that transplantable neoplasms in randomly bred laboratory mice could induce a strong immunity. On the basis of these observations, it was hypothesized that immune defense could play an important role in controlling the growth of cancer in man. This hypothesis was supported by the following findings: (1) spontaneous regression of established tumor (Everson and Cole, 1966); (2) delayed recurrence of rapidly progressive disease after successful treatment of the primary tumor (Lewis and Kiryabwire, 1968); (3) association of lymphocyte and other cellular infiltration into tumor with an improved prognosis (Black et al., 1956); (4) presence of tumor cells in lymphatics, peripheral blood, pleural cavity, and operative wounds of patients without subsequent development of metastases (Griffiths, et al., 1973; Roberts et al., 1967); and (5) inhibition of tumor autotransplants when mixed with autologous leukocytes or plasma in almost half the patients studied (Southam et al., 1966).

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Authors and Affiliations

  1. Division of Oncology, Department of Surgery, UCLA School of Medicine, University of California, Los Angeles, California, 90024, USA

    Rishab K. Gupta & Donald L. Morton

  2. Surgical Service, V. A. Medical Center, Sepulveda, California, 91343, USA

    Rishab K. Gupta & Donald L. Morton

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  1. Rishab K. Gupta
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  2. Donald L. Morton
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  1. Department of Molecular Immunology, Scripps Clinic and Research Foundation, 92037, La Jolla, California, USA

    Ralph A. Reisfeld

  2. Department of Pathology, College of Physicians and Surgeons, Columbia University, 10032, New York, New York, USA

    Soldano Ferrone

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Gupta, R.K., Morton, D.L. (1982). Clinical Significance of Tumor-Associated Antigens and Antitumor Antibodies in Human Malignant Melanoma. In: Reisfeld, R.A., Ferrone, S. (eds) Melanoma Antigens and Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4079-9_8

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