Protein Antigens of Mouse Melanomas

  • Douglas M. Gersten
  • John J. Marchalonis


Two lines of evidence suggest that B16 melanoma cells express immunological determinants. The first is that syngeneic C57BL/6 mice may be immunized outright to B16 preparations—either whole-cell (Fidler et al., 1977) or extract (Bystryn, 1978). The second is that cultured cells, when injected into B16-sensitized hosts, exhibit in vivo behavior different from that observed following administration into naïve hosts (Fidler et al.,1977; Gersten, 1980). It follows, then that B16 cells should possess unique molecules that are both absent from other C57BL/6 cells and immunogenic.


Protein Antigen Mouse Melanoma Melanoma Antigen Fraction Versus Bovine Serum Albumin Shed Material 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Douglas M. Gersten
    • 1
  • John J. Marchalonis
    • 2
  1. 1.Department of Pathology and National Biomedical Research FoundationGeorgetown UniversityUSA
  2. 2.Department of BiochemistryMedical University of South CarolinaCharlestonUSA

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