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Protein Antigens of Mouse Melanomas

  • Douglas M. Gersten
  • John J. Marchalonis

Abstract

Two lines of evidence suggest that B16 melanoma cells express immunological determinants. The first is that syngeneic C57BL/6 mice may be immunized outright to B16 preparations—either whole-cell (Fidler et al., 1977) or extract (Bystryn, 1978). The second is that cultured cells, when injected into B16-sensitized hosts, exhibit in vivo behavior different from that observed following administration into naïve hosts (Fidler et al.,1977; Gersten, 1980). It follows, then that B16 cells should possess unique molecules that are both absent from other C57BL/6 cells and immunogenic.

Keywords

Protein Antigen Mouse Melanoma Melanoma Antigen Fraction Versus Bovine Serum Albumin Shed Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Douglas M. Gersten
    • 1
  • John J. Marchalonis
    • 2
  1. 1.Department of Pathology and National Biomedical Research FoundationGeorgetown UniversityUSA
  2. 2.Department of BiochemistryMedical University of South CarolinaCharlestonUSA

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