Protein Antigens of Mouse Melanomas
Two lines of evidence suggest that B16 melanoma cells express immunological determinants. The first is that syngeneic C57BL/6 mice may be immunized outright to B16 preparations—either whole-cell (Fidler et al., 1977) or extract (Bystryn, 1978). The second is that cultured cells, when injected into B16-sensitized hosts, exhibit in vivo behavior different from that observed following administration into naïve hosts (Fidler et al.,1977; Gersten, 1980). It follows, then that B16 cells should possess unique molecules that are both absent from other C57BL/6 cells and immunogenic.
KeywordsProtein Antigen Mouse Melanoma Melanoma Antigen Fraction Versus Bovine Serum Albumin Shed Material
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