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The Features of Malignant Melanoma Organ-Specific Neoantigens Recognized by the Antitumor Immune Response of the Human Host

  • D. M. P. Thomson

Abstract

Human histocompatibility antigens have been defined with alloantisera from immunized subjects. Alloantisera have proved invaluable in defining the polymorphism of these antigens and monitoring their purification. Xenoantibodies to the human leukocyte antigen (HLA) complex, even to purified HLA antigens in sharp contradistinction, have not been reagents of great value in revealing HLA allospecificity (Sanderson, 1977). Likewise, by immunizing xenogeneic animals with experimental or human tumor materials, few, if any, tumor-antigen epitopes have been identified to which the tumor-bearing hosts respond. Cancer antigens to which the human responds, accordingly, may never be defined by immunizing xenogeneic animals with a hodgepodge of tumor materials.

Keywords

Human Leukocyte Antigen Affinity Column Antitumor Immune Response Histocompatibility Antigen Human Leukocyte Antigen Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. M. P. Thomson
    • 1
  1. 1.The Montreal General Hospital Research InstituteThe Montreal General HospitalMontrealCanada

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