Advertisement

Biological Studies of Antimelanoma Monoclonal Antibodies

  • Zenon Steplewski
  • Kenneth F. Mitchell
  • Hilary Koprowski

Abstract

The notion that tumors may bear antigens that do not exist on other cells of the host organism was originally inferred from the remissions that are occasionally seen in cancer and that were thought to occur because of an immune response to the tumor. The lymphocytic infiltration of the tumor bed in tumors such as melanoma also supports this hypothesis. All ideas on the diagnosis and immunotherapy of cancer are based on the assumption that such antigens exist. However, despite a great deal of work, experimental evidence for the existence of such tumor-specific or tumor-associated antigens remains scanty. Nevertheless, the necessary fundamental molecular basis that must underlie the expression of such antigens can be defined, and a rational approach to their study can be undertaken.

Keywords

Nude Mouse Melanoma Cell Melanoma Cell Line Hybrid Cell Line Lymphoid Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fuhrer, J. P., Ward, F. E., Mitchell, K. F., Steplewski, Z., and Koprowski, H., 1982, Structural variation in the DR antigens of human melanoma, Hum. Immunol. (in press).Google Scholar
  2. Herlyn, D., and Koprowski, H., 1981, Monoclonal anticolon carcinoma antibodies in complement-dependent cytotoxicity, Int. J. Cancer 27: 769.PubMedCrossRefGoogle Scholar
  3. Herlyn, D., Herlyn, M., Steplewski, Z., and Koprowski, H., 1979, Monoclonal antibodies in cell-mediated cytotoxicity against human melanoma and colorectal carcinoma, Eur. J. Immunol. 9: 657.PubMedCrossRefGoogle Scholar
  4. Herlyn, D., Steplewski, Z., Herlyn, M., and Koprowski, H., 1980, Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody, Cancer Res. 40: 717.PubMedGoogle Scholar
  5. Herlyn, M., Clark, W. H., Jr., Mastrangelo, M. J., Guerry, D., IV, Elder, D. E., LaRossa, D., Hamilton, R., Bondi, E., Tuthill, R., Steplewski, Z., and Koprowski, H., 1980, Specific immunoreactivity of hybridoma-secreted monoclonal anti-melanoma antibodies to cultured cells and freshly derived human cells, Cancer Res. 40: 3602.PubMedGoogle Scholar
  6. Imai, K., Molinaro, G. A., and Ferrone, S., 1980 Monoclonal antibodies to human melanoma-associated antigens, Transplant. Proc. 12: 380.PubMedGoogle Scholar
  7. Koprowski, H., Steplewski, Z., Herlyn, D., and Herlyn, M., 1978, Study of antibodies against human melanoma produced by somatic cell hybrids, Proc. Natl. Acad. Sci. U.S.A. 75: 3405.PubMedCrossRefGoogle Scholar
  8. Mitchell, K. F., Fuhrer, J. P., Steplewski, Z., and Koprowski, H., 1981a, Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies, Proc. Natl. Acad. Sci. U.S.A. 77: 7287.CrossRefGoogle Scholar
  9. Mitchell, K. F., Fuhrer, J. P., Steplewski, Z., and Koprowski, H., 1981b, Structural characterization of the “melanoma-specific” antigen detected by monoclonal antibody 691 I5-Nu4B, Mol. Immunol. 18: 207.CrossRefGoogle Scholar
  10. Steplewski, Z., 1980, Monoclonal antibodies to human tumor antigens, Transplant. Proc. 12: 384.PubMedGoogle Scholar
  11. Steplewski, Z., Herlyn, M., Herlyn, D., Clark, W. H., Jr., and Koprowski, H., Reactivity of monoclonal antimelanoma antibodies with melanoma cells freshly isolated from primary and metastatic melanoma,Eur. J. Immunol. 9:94.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Zenon Steplewski
    • 1
  • Kenneth F. Mitchell
    • 1
  • Hilary Koprowski
    • 1
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

Personalised recommendations