Biological Studies of Antimelanoma Monoclonal Antibodies
The notion that tumors may bear antigens that do not exist on other cells of the host organism was originally inferred from the remissions that are occasionally seen in cancer and that were thought to occur because of an immune response to the tumor. The lymphocytic infiltration of the tumor bed in tumors such as melanoma also supports this hypothesis. All ideas on the diagnosis and immunotherapy of cancer are based on the assumption that such antigens exist. However, despite a great deal of work, experimental evidence for the existence of such tumor-specific or tumor-associated antigens remains scanty. Nevertheless, the necessary fundamental molecular basis that must underlie the expression of such antigens can be defined, and a rational approach to their study can be undertaken.
KeywordsNude Mouse Melanoma Cell Melanoma Cell Line Hybrid Cell Line Lymphoid Cell Line
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