Molecular and Immunological Characterization of Human Melanoma-Associated Antigens

  • R. A. Reisfeld
  • D. R. Galloway
  • R. P. McCabe
  • Alton C. MorganJr.


During the last decade, there has been an increasing amount of evidence indicating that the neoplastic state is characterized by cell-surface changes, and this development has led to a concerted effort by many investigators to characterize cell-surface markers associated with human tumor cells. This research effort was further stimulated by the anticipation that the thorough characterization of human tumor markers may aid in the delineation of neoplastic transformation and advance the development of immunological approaches for diagnosis, prognosis, and thereapy of cancer. In this regard, the finding of antigens that are shed into the extracellular environment of tumor cells has received considerable attention (Grimm et al., 1976; Bystryn, 1977; McCabe et al., 1978; Gupta et al., 1979; Galloway et al., 1981a), since it may further aid in the development of approaches designed to improve detection and therapy of cancer.


Melanoma Cell Spend Culture Medium Immunological Characterization Oncofetal Antigen Culture Melanoma Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • R. A. Reisfeld
    • 1
  • D. R. Galloway
    • 1
  • R. P. McCabe
    • 1
  • Alton C. MorganJr.
    • 1
  1. 1.Department of Molecular ImmunologyScripps Clinic and Research FoundationLa JollaUSA

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