Monoclonal Antibodies to Human Melanoma-Associated Antigens: Elicitation and Evaluation with Immunochemically Defined Antigen Preparations
Rapid advancements have been made in the production of monoclonal antibodies with the advent of hybridoma technology, originally described by Köhler and Milstein (1975). Among these advances has been the production of monoclonal reagents to viral antigens (Wiktor and Koprowski, 1978), histocompatibility antigens (Galfre et al., 1977), haptens (Köhler and Milstein, 1976; Bottcher et al., 1980), and other cell-surface antigens (Milstein et al., 1979). The latter category includes antibodies to human tumor-associated antigens (TAAs); the production of such antibodies is a prominent goal of many investigators. The use of intact tumor cells for both elicitation and evaluation of hybridoma products has been a hallmark of most of these research efforts.
KeywordsMelanoma Cell Human Leukocyte Antigen Lymphoid Cell Human Melanoma Cell Histocompatibility Antigen
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